Immune complex disease in a chronic monkey study with a humanised, therapeutic antibody against CCL20 is associated with complement-containing drug aggregates

Despite the potential for the chemokine class as therapeutic targets in immune mediated disease, success has been limited. Many chemokines can bind to multiple receptors and many receptors have multiple ligands, with few exceptions. One of those exceptions is CCL20, which exclusively pairs to CCR6 a...

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Detalles Bibliográficos
Autores principales: Laffan, Susan B., Thomson, Andrew S., Mai, Shing, Fishman, Cindy, Kambara, Takahito, Nistala, Kiran, Raymond, James T., Chen, Shugui, Ramani, Thulasi, Pageon, Laura, Polsky, Rodd, Watkins, Mark, Ottolangui, Gemma, White, John R., Maier, Curtis, Herdman, Michael, Bouma, Gerben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180069/
https://www.ncbi.nlm.nih.gov/pubmed/32325480
http://dx.doi.org/10.1371/journal.pone.0231655

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