Genome Sequence of Human Cytomegalovirus Ig-KG-H2, a Variant of Strain KG Propagated in the Presence of Neutralizing Antibodies

Human cytomegalovirus shed in infant urine was isolated and serially passaged in fibroblasts in the presence or absence of neutralizing antibodies. Comparison of the genome sequences of representative viruses Ig-KG-H2 (passed with antibody) and ϕ-KG-B5 (passed without antibody) revealed the presence...

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Detalles Bibliográficos
Autores principales: Al Qaffas, Ahmed, Camiolo, Salvatore, Nichols, Jenna, Davison, Andrew J., Ourahmane, Amine, Cui, Xiaohong, Schleiss, Mark R., Hertel, Laura, Dittmer, Dirk P., McVoy, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Genome Sequences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180270/
https://www.ncbi.nlm.nih.gov/pubmed/32327516
http://dx.doi.org/10.1128/MRA.00063-20
Descripción
Sumario:Human cytomegalovirus shed in infant urine was isolated and serially passaged in fibroblasts in the presence or absence of neutralizing antibodies. Comparison of the genome sequences of representative viruses Ig-KG-H2 (passed with antibody) and ϕ-KG-B5 (passed without antibody) revealed the presence of several mutations in each virus.

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