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Prion‐like mechanisms in neurodegenerative disease: Implications for Huntington's disease therapy

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by a CAG repeat expansions in the huntingtin gene resulting in the synthesis of a misfolded form of the huntingtin protein (mHTT) which is toxic. The current treatments for HD are only palliative. Some of the p...

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Detalles Bibliográficos
Autores principales: Srinageshwar, Bhairavi, Petersen, Robert B., Dunbar, Gary L., Rossignol, Julien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180288/
https://www.ncbi.nlm.nih.gov/pubmed/31997581
http://dx.doi.org/10.1002/sctm.19-0248

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