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Prion‐like mechanisms in neurodegenerative disease: Implications for Huntington's disease therapy
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by a CAG repeat expansions in the huntingtin gene resulting in the synthesis of a misfolded form of the huntingtin protein (mHTT) which is toxic. The current treatments for HD are only palliative. Some of the p...
Autores principales: | Srinageshwar, Bhairavi, Petersen, Robert B., Dunbar, Gary L., Rossignol, Julien |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180288/ https://www.ncbi.nlm.nih.gov/pubmed/31997581 http://dx.doi.org/10.1002/sctm.19-0248 |
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