Sodium Butyrate Protects N2a Cells against Aβ Toxicity In Vitro

Alzheimer's disease (AD) is a common neurodegenerative disease. Aβ plays an important role in the pathogenesis of AD. Sodium butyrate (NaB) is a short-chain fatty acid salt that exerts neuroprotective effects such as anti-inflammatory, antioxidant, antiapoptotic, and cognitive improvement in ce...

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Autores principales: Sun, Jingxuan, Yuan, Boyu, Wu, Yancheng, Gong, Yuhong, Guo, Wenjin, Fu, Shoupeng, Luan, Yongxin, Wang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180402/
https://www.ncbi.nlm.nih.gov/pubmed/32377164
http://dx.doi.org/10.1155/2020/7605160
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author Sun, Jingxuan
Yuan, Boyu
Wu, Yancheng
Gong, Yuhong
Guo, Wenjin
Fu, Shoupeng
Luan, Yongxin
Wang, Wei
author_facet Sun, Jingxuan
Yuan, Boyu
Wu, Yancheng
Gong, Yuhong
Guo, Wenjin
Fu, Shoupeng
Luan, Yongxin
Wang, Wei
author_sort Sun, Jingxuan
collection PubMed
description Alzheimer's disease (AD) is a common neurodegenerative disease. Aβ plays an important role in the pathogenesis of AD. Sodium butyrate (NaB) is a short-chain fatty acid salt that exerts neuroprotective effects such as anti-inflammatory, antioxidant, antiapoptotic, and cognitive improvement in central nervous system diseases. The aim of this study is to research the protective effects of NaB on neurons against Aβ toxicity and to uncover the underlying mechanisms. The results showed that 2 mM NaB had a significant improvement effect on Aβ-induced N2a cell injury, by increasing cell viability and reducing ROS to reduce injury. In addition, by acting on the GPR109A receptor, NaB regulates the expression of AD-related genes such as APP, NEP, and BDNF. Therefore, NaB protects N2a cells from Aβ-induced cell damage through activating GPR109A, which provides an innovative idea for the treatment of AD.
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spelling pubmed-71804022020-05-06 Sodium Butyrate Protects N2a Cells against Aβ Toxicity In Vitro Sun, Jingxuan Yuan, Boyu Wu, Yancheng Gong, Yuhong Guo, Wenjin Fu, Shoupeng Luan, Yongxin Wang, Wei Mediators Inflamm Research Article Alzheimer's disease (AD) is a common neurodegenerative disease. Aβ plays an important role in the pathogenesis of AD. Sodium butyrate (NaB) is a short-chain fatty acid salt that exerts neuroprotective effects such as anti-inflammatory, antioxidant, antiapoptotic, and cognitive improvement in central nervous system diseases. The aim of this study is to research the protective effects of NaB on neurons against Aβ toxicity and to uncover the underlying mechanisms. The results showed that 2 mM NaB had a significant improvement effect on Aβ-induced N2a cell injury, by increasing cell viability and reducing ROS to reduce injury. In addition, by acting on the GPR109A receptor, NaB regulates the expression of AD-related genes such as APP, NEP, and BDNF. Therefore, NaB protects N2a cells from Aβ-induced cell damage through activating GPR109A, which provides an innovative idea for the treatment of AD. Hindawi 2020-04-15 /pmc/articles/PMC7180402/ /pubmed/32377164 http://dx.doi.org/10.1155/2020/7605160 Text en Copyright © 2020 Jingxuan Sun et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Sun, Jingxuan
Yuan, Boyu
Wu, Yancheng
Gong, Yuhong
Guo, Wenjin
Fu, Shoupeng
Luan, Yongxin
Wang, Wei
Sodium Butyrate Protects N2a Cells against Aβ Toxicity In Vitro
title Sodium Butyrate Protects N2a Cells against Aβ Toxicity In Vitro
title_full Sodium Butyrate Protects N2a Cells against Aβ Toxicity In Vitro
title_fullStr Sodium Butyrate Protects N2a Cells against Aβ Toxicity In Vitro
title_full_unstemmed Sodium Butyrate Protects N2a Cells against Aβ Toxicity In Vitro
title_short Sodium Butyrate Protects N2a Cells against Aβ Toxicity In Vitro
title_sort sodium butyrate protects n2a cells against aβ toxicity in vitro
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180402/
https://www.ncbi.nlm.nih.gov/pubmed/32377164
http://dx.doi.org/10.1155/2020/7605160
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