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NLRP3 Inflammasome and Its Central Role in the Cardiovascular Diseases
MATERIALS: The NLRP3 inflammasome controls the activation of the proteolytic enzyme caspase-1. Caspase-1 in turn regulates the maturation of the proinflammasome cytokines IL-1β and IL-18, which leads to an inflammatory response. We made a mini-review on the association of regulatory mechanisms of NL...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180412/ https://www.ncbi.nlm.nih.gov/pubmed/32377298 http://dx.doi.org/10.1155/2020/4293206 |
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author | Tong, Yeqing Wang, Zhihong Cai, Li Lin, Liangqiang Liu, Jiafa Cheng, Jinquan |
author_facet | Tong, Yeqing Wang, Zhihong Cai, Li Lin, Liangqiang Liu, Jiafa Cheng, Jinquan |
author_sort | Tong, Yeqing |
collection | PubMed |
description | MATERIALS: The NLRP3 inflammasome controls the activation of the proteolytic enzyme caspase-1. Caspase-1 in turn regulates the maturation of the proinflammasome cytokines IL-1β and IL-18, which leads to an inflammatory response. We made a mini-review on the association of regulatory mechanisms of NLRP3 inflammasome with the development of cardiovascular diseases systematically based on the recent research studies. Discussion. The inflammasome plays an indispensable role in the development of atherosclerosis, coronary heart diseases (CHD), and heart ischemia-reperfusion (I/R) injury, and NLRP3 inflammasome may become a new target for the prevention and treatment of cardiovascular diseases. Effective regulation of NLRP3 may help prevent or even treat cardiovascular diseases. CONCLUSION: This mini-review focuses on the association of regulatory mechanisms of NLRP3 inflammasome with the development of cardiovascular diseases, which may supply some important clues for future therapies and novel drug targets for cardiovascular diseases. |
format | Online Article Text |
id | pubmed-7180412 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-71804122020-05-06 NLRP3 Inflammasome and Its Central Role in the Cardiovascular Diseases Tong, Yeqing Wang, Zhihong Cai, Li Lin, Liangqiang Liu, Jiafa Cheng, Jinquan Oxid Med Cell Longev Review Article MATERIALS: The NLRP3 inflammasome controls the activation of the proteolytic enzyme caspase-1. Caspase-1 in turn regulates the maturation of the proinflammasome cytokines IL-1β and IL-18, which leads to an inflammatory response. We made a mini-review on the association of regulatory mechanisms of NLRP3 inflammasome with the development of cardiovascular diseases systematically based on the recent research studies. Discussion. The inflammasome plays an indispensable role in the development of atherosclerosis, coronary heart diseases (CHD), and heart ischemia-reperfusion (I/R) injury, and NLRP3 inflammasome may become a new target for the prevention and treatment of cardiovascular diseases. Effective regulation of NLRP3 may help prevent or even treat cardiovascular diseases. CONCLUSION: This mini-review focuses on the association of regulatory mechanisms of NLRP3 inflammasome with the development of cardiovascular diseases, which may supply some important clues for future therapies and novel drug targets for cardiovascular diseases. Hindawi 2020-04-14 /pmc/articles/PMC7180412/ /pubmed/32377298 http://dx.doi.org/10.1155/2020/4293206 Text en Copyright © 2020 Yeqing Tong et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Tong, Yeqing Wang, Zhihong Cai, Li Lin, Liangqiang Liu, Jiafa Cheng, Jinquan NLRP3 Inflammasome and Its Central Role in the Cardiovascular Diseases |
title | NLRP3 Inflammasome and Its Central Role in the Cardiovascular Diseases |
title_full | NLRP3 Inflammasome and Its Central Role in the Cardiovascular Diseases |
title_fullStr | NLRP3 Inflammasome and Its Central Role in the Cardiovascular Diseases |
title_full_unstemmed | NLRP3 Inflammasome and Its Central Role in the Cardiovascular Diseases |
title_short | NLRP3 Inflammasome and Its Central Role in the Cardiovascular Diseases |
title_sort | nlrp3 inflammasome and its central role in the cardiovascular diseases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180412/ https://www.ncbi.nlm.nih.gov/pubmed/32377298 http://dx.doi.org/10.1155/2020/4293206 |
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