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Sedative Effects of Latexes Obtained from Some Lactuca L. Species Growing in Turkey

Lactuca L. species belong to the Asteraceae family and these plants are traditionally used for therapeutic purposes around the world. The dried milky latex of L. serriola is known as “lettuce oil” and is used as a sedative in Turkey. This study aimed to evaluate the sedative effects and analyze the...

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Autores principales: Ilgün, Selen, Küpeli Akkol, Esra, Ilhan, Mert, Çiçek Polat, Derya, Baldemir Kılıç, Ayse, Coşkun, Maksut, Sobarzo-Sánchez, Eduardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180447/
https://www.ncbi.nlm.nih.gov/pubmed/32235622
http://dx.doi.org/10.3390/molecules25071587
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author Ilgün, Selen
Küpeli Akkol, Esra
Ilhan, Mert
Çiçek Polat, Derya
Baldemir Kılıç, Ayse
Coşkun, Maksut
Sobarzo-Sánchez, Eduardo
author_facet Ilgün, Selen
Küpeli Akkol, Esra
Ilhan, Mert
Çiçek Polat, Derya
Baldemir Kılıç, Ayse
Coşkun, Maksut
Sobarzo-Sánchez, Eduardo
author_sort Ilgün, Selen
collection PubMed
description Lactuca L. species belong to the Asteraceae family and these plants are traditionally used for therapeutic purposes around the world. The dried milky latex of L. serriola is known as “lettuce oil” and is used as a sedative in Turkey. This study aimed to evaluate the sedative effects and analyze the chemical compositions of latexes obtained from some Lactuca species growing in Turkey. The sedative effects were evaluated through various behavioral tests on mice. For this purpose, latexes were obtained from L. glareosa Boiss., L. viminea (L.) J. Presl and C. P, L. mulgedioides (Vis and Panćić) Boiss. and Kotschy ex. Boiss., L. saligna L., and L. serriola L. The latex from L. saligna showed the highest sedative effects, whilst L. serriola and L. viminea latexes also displayed significant sedative effects compared to the control group at a dose of 100 mg/kg. However, the latexes from L. glareosa and L. mulqedioides did not exhibit any sedative effects on mice. Characteristic sesquiterpene lactones (lactucin, lactucopicrin, 11,13β-dihydrolactucin, and 11,13β-dihydrolactucopicrin) were determined qualitatively and quantitatively by high-performance liquid chromatography (HPLC). Lactucin was identified as the main component.
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spelling pubmed-71804472020-05-01 Sedative Effects of Latexes Obtained from Some Lactuca L. Species Growing in Turkey Ilgün, Selen Küpeli Akkol, Esra Ilhan, Mert Çiçek Polat, Derya Baldemir Kılıç, Ayse Coşkun, Maksut Sobarzo-Sánchez, Eduardo Molecules Article Lactuca L. species belong to the Asteraceae family and these plants are traditionally used for therapeutic purposes around the world. The dried milky latex of L. serriola is known as “lettuce oil” and is used as a sedative in Turkey. This study aimed to evaluate the sedative effects and analyze the chemical compositions of latexes obtained from some Lactuca species growing in Turkey. The sedative effects were evaluated through various behavioral tests on mice. For this purpose, latexes were obtained from L. glareosa Boiss., L. viminea (L.) J. Presl and C. P, L. mulgedioides (Vis and Panćić) Boiss. and Kotschy ex. Boiss., L. saligna L., and L. serriola L. The latex from L. saligna showed the highest sedative effects, whilst L. serriola and L. viminea latexes also displayed significant sedative effects compared to the control group at a dose of 100 mg/kg. However, the latexes from L. glareosa and L. mulqedioides did not exhibit any sedative effects on mice. Characteristic sesquiterpene lactones (lactucin, lactucopicrin, 11,13β-dihydrolactucin, and 11,13β-dihydrolactucopicrin) were determined qualitatively and quantitatively by high-performance liquid chromatography (HPLC). Lactucin was identified as the main component. MDPI 2020-03-30 /pmc/articles/PMC7180447/ /pubmed/32235622 http://dx.doi.org/10.3390/molecules25071587 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ilgün, Selen
Küpeli Akkol, Esra
Ilhan, Mert
Çiçek Polat, Derya
Baldemir Kılıç, Ayse
Coşkun, Maksut
Sobarzo-Sánchez, Eduardo
Sedative Effects of Latexes Obtained from Some Lactuca L. Species Growing in Turkey
title Sedative Effects of Latexes Obtained from Some Lactuca L. Species Growing in Turkey
title_full Sedative Effects of Latexes Obtained from Some Lactuca L. Species Growing in Turkey
title_fullStr Sedative Effects of Latexes Obtained from Some Lactuca L. Species Growing in Turkey
title_full_unstemmed Sedative Effects of Latexes Obtained from Some Lactuca L. Species Growing in Turkey
title_short Sedative Effects of Latexes Obtained from Some Lactuca L. Species Growing in Turkey
title_sort sedative effects of latexes obtained from some lactuca l. species growing in turkey
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180447/
https://www.ncbi.nlm.nih.gov/pubmed/32235622
http://dx.doi.org/10.3390/molecules25071587
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