CD38 Causes Autophagic Flux Inhibition and Cardiac Dysfunction Through a Transcriptional Inhibition Pathway Under Hypoxia/Ischemia Conditions

Induced autophagy is protective against myocardial hypoxia/ischemia (H/I) injury, but evidence regarding the extent of autophagic clearance under H/I and the molecular mechanisms that influence autophagic flux has scarcely been presented. Here, we report that CD38 knockout improved cardiac function...

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Detalles Bibliográficos
Autores principales: Zhang, Xingyue, Li, Lingfei, Zhang, Qiong, Wei, Qinglin, Lin, Jiezhi, Jia, Jiezhi, Zhang, Junhui, Yan, Tiantian, Lv, Yanling, Jiang, Xupin, Zhang, Peng, Song, Huapei, Zhang, Dongxia, Huang, Yuesheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180518/
https://www.ncbi.nlm.nih.gov/pubmed/32363189
http://dx.doi.org/10.3389/fcell.2020.00191

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