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Malignant solitary fibrous tumor occurring in the mediastinal pleura showing NAB2ex4‐STAT6ex2 fusion and negative STAT6 immunohistochemistry: A case report

Solitary fibrous tumor (SFT) is a rare clinical tumor, defined as a mesenchymal tumor of fibroblastic origin. A classic SFT is benign in most cases, but its clinical behavior is unpredictable. Lately, molecular analyses has discovered that almost all SFTs harbor an NAB2‐STAT6 fusion gene, which is c...

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Autores principales: Zhang, Peng, Xiong, Kai, Lv, Peng, Zhang, Hui, Wang, Yuanguo, Yang, Zhaoyu, Tao, Ziyou, Song, Wenjing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180598/
https://www.ncbi.nlm.nih.gov/pubmed/32196965
http://dx.doi.org/10.1111/1759-7714.13395
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author Zhang, Peng
Xiong, Kai
Lv, Peng
Zhang, Hui
Wang, Yuanguo
Yang, Zhaoyu
Tao, Ziyou
Zhang, Peng
Song, Wenjing
author_facet Zhang, Peng
Xiong, Kai
Lv, Peng
Zhang, Hui
Wang, Yuanguo
Yang, Zhaoyu
Tao, Ziyou
Zhang, Peng
Song, Wenjing
author_sort Zhang, Peng
collection PubMed
description Solitary fibrous tumor (SFT) is a rare clinical tumor, defined as a mesenchymal tumor of fibroblastic origin. A classic SFT is benign in most cases, but its clinical behavior is unpredictable. Lately, molecular analyses has discovered that almost all SFTs harbor an NAB2‐STAT6 fusion gene, which is considered specific to this tumor type. Recent studies have suggested that nuclear STAT6 immunoreactivity is a highly sensitive and specific marker of SFTs and can be helpful when diagnosis is inconclusive by conventional methods. We herein report the case of a rare malignant solitary fibrous tumor occurring in the mediastinal pleura. An 82‐year‐old Chinese man with intermittent breathlessness was referred to our hospital. Chest CT showed a significantly enhanced irregular huge soft tissue mass in the anterior mediastinal area. After radical resection, the immunohistochemistry staining results of the sample showed that STAT6 was negative. The final diagnosis was confirmed by qualitative endpoint reverse transcriptase‐polymerase chain reaction technique, showing positive NAB2ex4‐STAT6ex2 fusion.
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spelling pubmed-71805982020-05-01 Malignant solitary fibrous tumor occurring in the mediastinal pleura showing NAB2ex4‐STAT6ex2 fusion and negative STAT6 immunohistochemistry: A case report Zhang, Peng Xiong, Kai Lv, Peng Zhang, Hui Wang, Yuanguo Yang, Zhaoyu Tao, Ziyou Zhang, Peng Song, Wenjing Thorac Cancer Case Reports Solitary fibrous tumor (SFT) is a rare clinical tumor, defined as a mesenchymal tumor of fibroblastic origin. A classic SFT is benign in most cases, but its clinical behavior is unpredictable. Lately, molecular analyses has discovered that almost all SFTs harbor an NAB2‐STAT6 fusion gene, which is considered specific to this tumor type. Recent studies have suggested that nuclear STAT6 immunoreactivity is a highly sensitive and specific marker of SFTs and can be helpful when diagnosis is inconclusive by conventional methods. We herein report the case of a rare malignant solitary fibrous tumor occurring in the mediastinal pleura. An 82‐year‐old Chinese man with intermittent breathlessness was referred to our hospital. Chest CT showed a significantly enhanced irregular huge soft tissue mass in the anterior mediastinal area. After radical resection, the immunohistochemistry staining results of the sample showed that STAT6 was negative. The final diagnosis was confirmed by qualitative endpoint reverse transcriptase‐polymerase chain reaction technique, showing positive NAB2ex4‐STAT6ex2 fusion. John Wiley & Sons Australia, Ltd 2020-03-20 2020-05 /pmc/articles/PMC7180598/ /pubmed/32196965 http://dx.doi.org/10.1111/1759-7714.13395 Text en © 2020 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Zhang, Peng
Xiong, Kai
Lv, Peng
Zhang, Hui
Wang, Yuanguo
Yang, Zhaoyu
Tao, Ziyou
Zhang, Peng
Song, Wenjing
Malignant solitary fibrous tumor occurring in the mediastinal pleura showing NAB2ex4‐STAT6ex2 fusion and negative STAT6 immunohistochemistry: A case report
title Malignant solitary fibrous tumor occurring in the mediastinal pleura showing NAB2ex4‐STAT6ex2 fusion and negative STAT6 immunohistochemistry: A case report
title_full Malignant solitary fibrous tumor occurring in the mediastinal pleura showing NAB2ex4‐STAT6ex2 fusion and negative STAT6 immunohistochemistry: A case report
title_fullStr Malignant solitary fibrous tumor occurring in the mediastinal pleura showing NAB2ex4‐STAT6ex2 fusion and negative STAT6 immunohistochemistry: A case report
title_full_unstemmed Malignant solitary fibrous tumor occurring in the mediastinal pleura showing NAB2ex4‐STAT6ex2 fusion and negative STAT6 immunohistochemistry: A case report
title_short Malignant solitary fibrous tumor occurring in the mediastinal pleura showing NAB2ex4‐STAT6ex2 fusion and negative STAT6 immunohistochemistry: A case report
title_sort malignant solitary fibrous tumor occurring in the mediastinal pleura showing nab2ex4‐stat6ex2 fusion and negative stat6 immunohistochemistry: a case report
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180598/
https://www.ncbi.nlm.nih.gov/pubmed/32196965
http://dx.doi.org/10.1111/1759-7714.13395
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