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Herpes zoster granulomatous dermatitis in metastatic lung cancer treated with nivolumab: A case report
Granulomatous dermatitis (GD) is the most common among a variety of skin reactions that may occur in the varicella‐zoster virus (VZV) reactivation area. It is thought that the formation of granulomas may be the result of a delayed hypersensitivity reaction to viral envelope glycoproteins. Immune che...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons Australia, Ltd
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180604/ https://www.ncbi.nlm.nih.gov/pubmed/32141197 http://dx.doi.org/10.1111/1759-7714.13377 |
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author | Gozzi, Elisa Rossi, Luigi Angelini, Francesco Leoni, Valentina Trenta, Patrizia Cimino, Giuseppe Tomao, Silverio |
author_facet | Gozzi, Elisa Rossi, Luigi Angelini, Francesco Leoni, Valentina Trenta, Patrizia Cimino, Giuseppe Tomao, Silverio |
author_sort | Gozzi, Elisa |
collection | PubMed |
description | Granulomatous dermatitis (GD) is the most common among a variety of skin reactions that may occur in the varicella‐zoster virus (VZV) reactivation area. It is thought that the formation of granulomas may be the result of a delayed hypersensitivity reaction to viral envelope glycoproteins. Immune checkpoint inhibitors (ICIs), such as nivolumab stimulate T cells and promote hypersensitivity reactions, leading to the formation of granulomas in VZV wrapping proteins, thus triggering VZV‐GD. Few cases of the use of ICIs in patients diagnosed with VZV‐GD have been reported in the literature. Here, we report the clinical case of a patient with metastatic lung cancer which was treated with nivolumab who subsequently developed VZV‐GD. Accurate clinical diagnosis and prompt treatment with antiviral agents have resulted in a complete resolution of the clinical picture. KEY POINTS: SIGNIFICANT FINDINGS: Treatment with ICIs may result in VZV reactivation. Accurate differential diagnosis and early treatment led to the resolution of VZV‐GD. WHAT THIS STUDY ADDS: Few cases of ICI and VZV reactivation have been reported in the literature. Full and timely resolution of VZV‐GD allowed the continuation of ICI treatment. |
format | Online Article Text |
id | pubmed-7180604 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley & Sons Australia, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-71806042020-05-01 Herpes zoster granulomatous dermatitis in metastatic lung cancer treated with nivolumab: A case report Gozzi, Elisa Rossi, Luigi Angelini, Francesco Leoni, Valentina Trenta, Patrizia Cimino, Giuseppe Tomao, Silverio Thorac Cancer Case Reports Granulomatous dermatitis (GD) is the most common among a variety of skin reactions that may occur in the varicella‐zoster virus (VZV) reactivation area. It is thought that the formation of granulomas may be the result of a delayed hypersensitivity reaction to viral envelope glycoproteins. Immune checkpoint inhibitors (ICIs), such as nivolumab stimulate T cells and promote hypersensitivity reactions, leading to the formation of granulomas in VZV wrapping proteins, thus triggering VZV‐GD. Few cases of the use of ICIs in patients diagnosed with VZV‐GD have been reported in the literature. Here, we report the clinical case of a patient with metastatic lung cancer which was treated with nivolumab who subsequently developed VZV‐GD. Accurate clinical diagnosis and prompt treatment with antiviral agents have resulted in a complete resolution of the clinical picture. KEY POINTS: SIGNIFICANT FINDINGS: Treatment with ICIs may result in VZV reactivation. Accurate differential diagnosis and early treatment led to the resolution of VZV‐GD. WHAT THIS STUDY ADDS: Few cases of ICI and VZV reactivation have been reported in the literature. Full and timely resolution of VZV‐GD allowed the continuation of ICI treatment. John Wiley & Sons Australia, Ltd 2020-03-05 2020-05 /pmc/articles/PMC7180604/ /pubmed/32141197 http://dx.doi.org/10.1111/1759-7714.13377 Text en © 2020 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Reports Gozzi, Elisa Rossi, Luigi Angelini, Francesco Leoni, Valentina Trenta, Patrizia Cimino, Giuseppe Tomao, Silverio Herpes zoster granulomatous dermatitis in metastatic lung cancer treated with nivolumab: A case report |
title | Herpes zoster granulomatous dermatitis in metastatic lung cancer treated with nivolumab: A case report |
title_full | Herpes zoster granulomatous dermatitis in metastatic lung cancer treated with nivolumab: A case report |
title_fullStr | Herpes zoster granulomatous dermatitis in metastatic lung cancer treated with nivolumab: A case report |
title_full_unstemmed | Herpes zoster granulomatous dermatitis in metastatic lung cancer treated with nivolumab: A case report |
title_short | Herpes zoster granulomatous dermatitis in metastatic lung cancer treated with nivolumab: A case report |
title_sort | herpes zoster granulomatous dermatitis in metastatic lung cancer treated with nivolumab: a case report |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180604/ https://www.ncbi.nlm.nih.gov/pubmed/32141197 http://dx.doi.org/10.1111/1759-7714.13377 |
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