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Synthesis of Pyrrolidine Monocyclic Analogues of Pochonicine and Its Stereoisomers: Pursuit of Simplified Structures and Potent β-N-Acetylhexosaminidase Inhibition

Ten pairs of pyrrolidine analogues of pochonicine and its stereoisomers have been synthesized from four enantiomeric pairs of polyhydroxylated cyclic nitrones. Among the ten N-acetylamino pyrrolidine analogues, only compounds with 2,5-dideoxy-2,5-imino-d-mannitol (DMDP) and pochonicine (1) configura...

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Detalles Bibliográficos
Autores principales:	Yan, Xin, Shimadate, Yuna, Kato, Atsushi, Li, Yi-Xian, Jia, Yue-Mei, Fleet, George W. J., Yu, Chu-Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180638/ https://www.ncbi.nlm.nih.gov/pubmed/32218360 http://dx.doi.org/10.3390/molecules25071498

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