Cargando…

Sex-Related Differences of the Effect of Lipoproteins and Apolipoproteins on 10-Year Cardiovascular Disease Risk; Insights from the ATTICA Study (2002–2012)

The sex-specific effect of lipid-related biomarkers on 10-year first fatal/non fatal cardiovascular disease (CVD) incidence was evaluated. ATTICA study was conducted during 2001–2012. n = 1514 men and n = 1528 women (>18 years) from greater Athens area, Greece were recruited. Follow-up (2011–2012...

Descripción completa

Detalles Bibliográficos
Autores principales: Kouvari, Matina, Panagiotakos, Demosthenes B., Chrysohoou, Christina, Georgousopoulou, Ekavi N., Tousoulis, Dimitrios, Pitsavos, Christos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180686/
https://www.ncbi.nlm.nih.gov/pubmed/32225033
http://dx.doi.org/10.3390/molecules25071506
_version_ 1783525877426946048
author Kouvari, Matina
Panagiotakos, Demosthenes B.
Chrysohoou, Christina
Georgousopoulou, Ekavi N.
Tousoulis, Dimitrios
Pitsavos, Christos
author_facet Kouvari, Matina
Panagiotakos, Demosthenes B.
Chrysohoou, Christina
Georgousopoulou, Ekavi N.
Tousoulis, Dimitrios
Pitsavos, Christos
author_sort Kouvari, Matina
collection PubMed
description The sex-specific effect of lipid-related biomarkers on 10-year first fatal/non fatal cardiovascular disease (CVD) incidence was evaluated. ATTICA study was conducted during 2001–2012. n = 1514 men and n = 1528 women (>18 years) from greater Athens area, Greece were recruited. Follow-up (2011–2012) was achieved in n = 2020 participants. Baseline lipid profile was measured. Overall CVD event was 15.5% (n = 317) (19.7% in men and 11.7% in women, p < 0.001). High density lipoprotein cholesterol (HDL-C) and triglycerides (TAG) were independently associated with CVD in women; per 10 mg/dL HDL-C increase, hazard ratio (HR) = 0.73, 95% confidence interval (95% CI) (0.53, 1.00); and per 10 mg/dL TAG increase, HR = 1.10, 95% CI (1.00, 1.21). Apolipoprotein A1 (ApoA1) (per 10 mg/dL increase, HR = 0.90, 95% CI (0.81, 0.99)) was inversely associated with CVD in women, while a positive association with apolipoprotein B100 (ApoB100) was observed only in men (per 10 mg/dL increase, HR = 1.10, 95% CI (1.00, 1.21)). Non-HDL-C was associated with CVD in the total sample (HR = 1.10, 95% CI (1.00, 1.21)) and in women (HR = 1.10, 95% CI (1.00, 1.21)); a steep increase in HR was observed for values >185 mg/dL in the total sample and in men, while in women, a raise in CVD risk was observed from lower values (>145 mg/dL). As for non-HDL-C/HDL-C and TC/HDL-C ratios, similar trends were observed. Beyond the common cholesterol-adjusted risk scores, reclassifying total CVD risk according to other lipid markers may contribute to early CVD prevention. Biomarkers such as HDL-C, non-HDL-C, and TAG should be more closely monitored in women.
format Online
Article
Text
id pubmed-7180686
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-71806862020-05-01 Sex-Related Differences of the Effect of Lipoproteins and Apolipoproteins on 10-Year Cardiovascular Disease Risk; Insights from the ATTICA Study (2002–2012) Kouvari, Matina Panagiotakos, Demosthenes B. Chrysohoou, Christina Georgousopoulou, Ekavi N. Tousoulis, Dimitrios Pitsavos, Christos Molecules Article The sex-specific effect of lipid-related biomarkers on 10-year first fatal/non fatal cardiovascular disease (CVD) incidence was evaluated. ATTICA study was conducted during 2001–2012. n = 1514 men and n = 1528 women (>18 years) from greater Athens area, Greece were recruited. Follow-up (2011–2012) was achieved in n = 2020 participants. Baseline lipid profile was measured. Overall CVD event was 15.5% (n = 317) (19.7% in men and 11.7% in women, p < 0.001). High density lipoprotein cholesterol (HDL-C) and triglycerides (TAG) were independently associated with CVD in women; per 10 mg/dL HDL-C increase, hazard ratio (HR) = 0.73, 95% confidence interval (95% CI) (0.53, 1.00); and per 10 mg/dL TAG increase, HR = 1.10, 95% CI (1.00, 1.21). Apolipoprotein A1 (ApoA1) (per 10 mg/dL increase, HR = 0.90, 95% CI (0.81, 0.99)) was inversely associated with CVD in women, while a positive association with apolipoprotein B100 (ApoB100) was observed only in men (per 10 mg/dL increase, HR = 1.10, 95% CI (1.00, 1.21)). Non-HDL-C was associated with CVD in the total sample (HR = 1.10, 95% CI (1.00, 1.21)) and in women (HR = 1.10, 95% CI (1.00, 1.21)); a steep increase in HR was observed for values >185 mg/dL in the total sample and in men, while in women, a raise in CVD risk was observed from lower values (>145 mg/dL). As for non-HDL-C/HDL-C and TC/HDL-C ratios, similar trends were observed. Beyond the common cholesterol-adjusted risk scores, reclassifying total CVD risk according to other lipid markers may contribute to early CVD prevention. Biomarkers such as HDL-C, non-HDL-C, and TAG should be more closely monitored in women. MDPI 2020-03-26 /pmc/articles/PMC7180686/ /pubmed/32225033 http://dx.doi.org/10.3390/molecules25071506 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kouvari, Matina
Panagiotakos, Demosthenes B.
Chrysohoou, Christina
Georgousopoulou, Ekavi N.
Tousoulis, Dimitrios
Pitsavos, Christos
Sex-Related Differences of the Effect of Lipoproteins and Apolipoproteins on 10-Year Cardiovascular Disease Risk; Insights from the ATTICA Study (2002–2012)
title Sex-Related Differences of the Effect of Lipoproteins and Apolipoproteins on 10-Year Cardiovascular Disease Risk; Insights from the ATTICA Study (2002–2012)
title_full Sex-Related Differences of the Effect of Lipoproteins and Apolipoproteins on 10-Year Cardiovascular Disease Risk; Insights from the ATTICA Study (2002–2012)
title_fullStr Sex-Related Differences of the Effect of Lipoproteins and Apolipoproteins on 10-Year Cardiovascular Disease Risk; Insights from the ATTICA Study (2002–2012)
title_full_unstemmed Sex-Related Differences of the Effect of Lipoproteins and Apolipoproteins on 10-Year Cardiovascular Disease Risk; Insights from the ATTICA Study (2002–2012)
title_short Sex-Related Differences of the Effect of Lipoproteins and Apolipoproteins on 10-Year Cardiovascular Disease Risk; Insights from the ATTICA Study (2002–2012)
title_sort sex-related differences of the effect of lipoproteins and apolipoproteins on 10-year cardiovascular disease risk; insights from the attica study (2002–2012)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180686/
https://www.ncbi.nlm.nih.gov/pubmed/32225033
http://dx.doi.org/10.3390/molecules25071506
work_keys_str_mv AT kouvarimatina sexrelateddifferencesoftheeffectoflipoproteinsandapolipoproteinson10yearcardiovasculardiseaseriskinsightsfromtheatticastudy20022012
AT panagiotakosdemosthenesb sexrelateddifferencesoftheeffectoflipoproteinsandapolipoproteinson10yearcardiovasculardiseaseriskinsightsfromtheatticastudy20022012
AT chrysohoouchristina sexrelateddifferencesoftheeffectoflipoproteinsandapolipoproteinson10yearcardiovasculardiseaseriskinsightsfromtheatticastudy20022012
AT georgousopoulouekavin sexrelateddifferencesoftheeffectoflipoproteinsandapolipoproteinson10yearcardiovasculardiseaseriskinsightsfromtheatticastudy20022012
AT tousoulisdimitrios sexrelateddifferencesoftheeffectoflipoproteinsandapolipoproteinson10yearcardiovasculardiseaseriskinsightsfromtheatticastudy20022012
AT pitsavoschristos sexrelateddifferencesoftheeffectoflipoproteinsandapolipoproteinson10yearcardiovasculardiseaseriskinsightsfromtheatticastudy20022012