Cargando…
Sex-Related Differences of the Effect of Lipoproteins and Apolipoproteins on 10-Year Cardiovascular Disease Risk; Insights from the ATTICA Study (2002–2012)
The sex-specific effect of lipid-related biomarkers on 10-year first fatal/non fatal cardiovascular disease (CVD) incidence was evaluated. ATTICA study was conducted during 2001–2012. n = 1514 men and n = 1528 women (>18 years) from greater Athens area, Greece were recruited. Follow-up (2011–2012...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180686/ https://www.ncbi.nlm.nih.gov/pubmed/32225033 http://dx.doi.org/10.3390/molecules25071506 |
_version_ | 1783525877426946048 |
---|---|
author | Kouvari, Matina Panagiotakos, Demosthenes B. Chrysohoou, Christina Georgousopoulou, Ekavi N. Tousoulis, Dimitrios Pitsavos, Christos |
author_facet | Kouvari, Matina Panagiotakos, Demosthenes B. Chrysohoou, Christina Georgousopoulou, Ekavi N. Tousoulis, Dimitrios Pitsavos, Christos |
author_sort | Kouvari, Matina |
collection | PubMed |
description | The sex-specific effect of lipid-related biomarkers on 10-year first fatal/non fatal cardiovascular disease (CVD) incidence was evaluated. ATTICA study was conducted during 2001–2012. n = 1514 men and n = 1528 women (>18 years) from greater Athens area, Greece were recruited. Follow-up (2011–2012) was achieved in n = 2020 participants. Baseline lipid profile was measured. Overall CVD event was 15.5% (n = 317) (19.7% in men and 11.7% in women, p < 0.001). High density lipoprotein cholesterol (HDL-C) and triglycerides (TAG) were independently associated with CVD in women; per 10 mg/dL HDL-C increase, hazard ratio (HR) = 0.73, 95% confidence interval (95% CI) (0.53, 1.00); and per 10 mg/dL TAG increase, HR = 1.10, 95% CI (1.00, 1.21). Apolipoprotein A1 (ApoA1) (per 10 mg/dL increase, HR = 0.90, 95% CI (0.81, 0.99)) was inversely associated with CVD in women, while a positive association with apolipoprotein B100 (ApoB100) was observed only in men (per 10 mg/dL increase, HR = 1.10, 95% CI (1.00, 1.21)). Non-HDL-C was associated with CVD in the total sample (HR = 1.10, 95% CI (1.00, 1.21)) and in women (HR = 1.10, 95% CI (1.00, 1.21)); a steep increase in HR was observed for values >185 mg/dL in the total sample and in men, while in women, a raise in CVD risk was observed from lower values (>145 mg/dL). As for non-HDL-C/HDL-C and TC/HDL-C ratios, similar trends were observed. Beyond the common cholesterol-adjusted risk scores, reclassifying total CVD risk according to other lipid markers may contribute to early CVD prevention. Biomarkers such as HDL-C, non-HDL-C, and TAG should be more closely monitored in women. |
format | Online Article Text |
id | pubmed-7180686 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71806862020-05-01 Sex-Related Differences of the Effect of Lipoproteins and Apolipoproteins on 10-Year Cardiovascular Disease Risk; Insights from the ATTICA Study (2002–2012) Kouvari, Matina Panagiotakos, Demosthenes B. Chrysohoou, Christina Georgousopoulou, Ekavi N. Tousoulis, Dimitrios Pitsavos, Christos Molecules Article The sex-specific effect of lipid-related biomarkers on 10-year first fatal/non fatal cardiovascular disease (CVD) incidence was evaluated. ATTICA study was conducted during 2001–2012. n = 1514 men and n = 1528 women (>18 years) from greater Athens area, Greece were recruited. Follow-up (2011–2012) was achieved in n = 2020 participants. Baseline lipid profile was measured. Overall CVD event was 15.5% (n = 317) (19.7% in men and 11.7% in women, p < 0.001). High density lipoprotein cholesterol (HDL-C) and triglycerides (TAG) were independently associated with CVD in women; per 10 mg/dL HDL-C increase, hazard ratio (HR) = 0.73, 95% confidence interval (95% CI) (0.53, 1.00); and per 10 mg/dL TAG increase, HR = 1.10, 95% CI (1.00, 1.21). Apolipoprotein A1 (ApoA1) (per 10 mg/dL increase, HR = 0.90, 95% CI (0.81, 0.99)) was inversely associated with CVD in women, while a positive association with apolipoprotein B100 (ApoB100) was observed only in men (per 10 mg/dL increase, HR = 1.10, 95% CI (1.00, 1.21)). Non-HDL-C was associated with CVD in the total sample (HR = 1.10, 95% CI (1.00, 1.21)) and in women (HR = 1.10, 95% CI (1.00, 1.21)); a steep increase in HR was observed for values >185 mg/dL in the total sample and in men, while in women, a raise in CVD risk was observed from lower values (>145 mg/dL). As for non-HDL-C/HDL-C and TC/HDL-C ratios, similar trends were observed. Beyond the common cholesterol-adjusted risk scores, reclassifying total CVD risk according to other lipid markers may contribute to early CVD prevention. Biomarkers such as HDL-C, non-HDL-C, and TAG should be more closely monitored in women. MDPI 2020-03-26 /pmc/articles/PMC7180686/ /pubmed/32225033 http://dx.doi.org/10.3390/molecules25071506 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kouvari, Matina Panagiotakos, Demosthenes B. Chrysohoou, Christina Georgousopoulou, Ekavi N. Tousoulis, Dimitrios Pitsavos, Christos Sex-Related Differences of the Effect of Lipoproteins and Apolipoproteins on 10-Year Cardiovascular Disease Risk; Insights from the ATTICA Study (2002–2012) |
title | Sex-Related Differences of the Effect of Lipoproteins and Apolipoproteins on 10-Year Cardiovascular Disease Risk; Insights from the ATTICA Study (2002–2012) |
title_full | Sex-Related Differences of the Effect of Lipoproteins and Apolipoproteins on 10-Year Cardiovascular Disease Risk; Insights from the ATTICA Study (2002–2012) |
title_fullStr | Sex-Related Differences of the Effect of Lipoproteins and Apolipoproteins on 10-Year Cardiovascular Disease Risk; Insights from the ATTICA Study (2002–2012) |
title_full_unstemmed | Sex-Related Differences of the Effect of Lipoproteins and Apolipoproteins on 10-Year Cardiovascular Disease Risk; Insights from the ATTICA Study (2002–2012) |
title_short | Sex-Related Differences of the Effect of Lipoproteins and Apolipoproteins on 10-Year Cardiovascular Disease Risk; Insights from the ATTICA Study (2002–2012) |
title_sort | sex-related differences of the effect of lipoproteins and apolipoproteins on 10-year cardiovascular disease risk; insights from the attica study (2002–2012) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180686/ https://www.ncbi.nlm.nih.gov/pubmed/32225033 http://dx.doi.org/10.3390/molecules25071506 |
work_keys_str_mv | AT kouvarimatina sexrelateddifferencesoftheeffectoflipoproteinsandapolipoproteinson10yearcardiovasculardiseaseriskinsightsfromtheatticastudy20022012 AT panagiotakosdemosthenesb sexrelateddifferencesoftheeffectoflipoproteinsandapolipoproteinson10yearcardiovasculardiseaseriskinsightsfromtheatticastudy20022012 AT chrysohoouchristina sexrelateddifferencesoftheeffectoflipoproteinsandapolipoproteinson10yearcardiovasculardiseaseriskinsightsfromtheatticastudy20022012 AT georgousopoulouekavin sexrelateddifferencesoftheeffectoflipoproteinsandapolipoproteinson10yearcardiovasculardiseaseriskinsightsfromtheatticastudy20022012 AT tousoulisdimitrios sexrelateddifferencesoftheeffectoflipoproteinsandapolipoproteinson10yearcardiovasculardiseaseriskinsightsfromtheatticastudy20022012 AT pitsavoschristos sexrelateddifferencesoftheeffectoflipoproteinsandapolipoproteinson10yearcardiovasculardiseaseriskinsightsfromtheatticastudy20022012 |