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Encapsulation for Cancer Therapy

The current rapid advancement of numerous nanotechnology tools is being employed in treatment of many terminal diseases such as cancer. Nanocapsules (NCs) containing an anti-cancer drug offer a very promising alternative to conventional treatments, mostly due to their targeted delivery and precise a...

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Autores principales: Montané, Xavier, Bajek, Anna, Roszkowski, Krzysztof, Montornés, Josep M., Giamberini, Marta, Roszkowski, Szymon, Kowalczyk, Oliwia, Garcia-Valls, Ricard, Tylkowski, Bartosz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180689/
https://www.ncbi.nlm.nih.gov/pubmed/32244513
http://dx.doi.org/10.3390/molecules25071605
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author Montané, Xavier
Bajek, Anna
Roszkowski, Krzysztof
Montornés, Josep M.
Giamberini, Marta
Roszkowski, Szymon
Kowalczyk, Oliwia
Garcia-Valls, Ricard
Tylkowski, Bartosz
author_facet Montané, Xavier
Bajek, Anna
Roszkowski, Krzysztof
Montornés, Josep M.
Giamberini, Marta
Roszkowski, Szymon
Kowalczyk, Oliwia
Garcia-Valls, Ricard
Tylkowski, Bartosz
author_sort Montané, Xavier
collection PubMed
description The current rapid advancement of numerous nanotechnology tools is being employed in treatment of many terminal diseases such as cancer. Nanocapsules (NCs) containing an anti-cancer drug offer a very promising alternative to conventional treatments, mostly due to their targeted delivery and precise action, and thereby they can be used in distinct applications: as biosensors or in medical imaging, allowing for cancer detection as well as agents/carriers in targeted drug delivery. The possibility of using different systems—inorganic nanoparticles, dendrimers, proteins, polymeric micelles, liposomes, carbon nanotubes (CNTs), quantum dots (QDs), biopolymeric nanoparticles and their combinations—offers multiple benefits to early cancer detection as well as controlled drug delivery to specific locations. This review focused on the key and recent progress in the encapsulation of anticancer drugs that include methods of preparation, drug loading and drug release mechanism on the presented nanosystems. Furthermore, the future directions in applications of various nanoparticles are highlighted.
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spelling pubmed-71806892020-05-01 Encapsulation for Cancer Therapy Montané, Xavier Bajek, Anna Roszkowski, Krzysztof Montornés, Josep M. Giamberini, Marta Roszkowski, Szymon Kowalczyk, Oliwia Garcia-Valls, Ricard Tylkowski, Bartosz Molecules Review The current rapid advancement of numerous nanotechnology tools is being employed in treatment of many terminal diseases such as cancer. Nanocapsules (NCs) containing an anti-cancer drug offer a very promising alternative to conventional treatments, mostly due to their targeted delivery and precise action, and thereby they can be used in distinct applications: as biosensors or in medical imaging, allowing for cancer detection as well as agents/carriers in targeted drug delivery. The possibility of using different systems—inorganic nanoparticles, dendrimers, proteins, polymeric micelles, liposomes, carbon nanotubes (CNTs), quantum dots (QDs), biopolymeric nanoparticles and their combinations—offers multiple benefits to early cancer detection as well as controlled drug delivery to specific locations. This review focused on the key and recent progress in the encapsulation of anticancer drugs that include methods of preparation, drug loading and drug release mechanism on the presented nanosystems. Furthermore, the future directions in applications of various nanoparticles are highlighted. MDPI 2020-03-31 /pmc/articles/PMC7180689/ /pubmed/32244513 http://dx.doi.org/10.3390/molecules25071605 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Montané, Xavier
Bajek, Anna
Roszkowski, Krzysztof
Montornés, Josep M.
Giamberini, Marta
Roszkowski, Szymon
Kowalczyk, Oliwia
Garcia-Valls, Ricard
Tylkowski, Bartosz
Encapsulation for Cancer Therapy
title Encapsulation for Cancer Therapy
title_full Encapsulation for Cancer Therapy
title_fullStr Encapsulation for Cancer Therapy
title_full_unstemmed Encapsulation for Cancer Therapy
title_short Encapsulation for Cancer Therapy
title_sort encapsulation for cancer therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180689/
https://www.ncbi.nlm.nih.gov/pubmed/32244513
http://dx.doi.org/10.3390/molecules25071605
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