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Development of a 3D Anthropomorphic Phantom Generator for Microwave Imaging Applications of the Head and Neck Region

The development of 3D anthropomorphic head and neck phantoms is of crucial and timely importance to explore novel imaging techniques, such as radar-based MicroWave Imaging (MWI), which have the potential to accurately diagnose Cervical Lymph Nodes (CLNs) in a neoadjuvant and non-invasive manner. We...

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Autores principales: Pelicano, Ana Catarina, Conceição, Raquel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180700/
https://www.ncbi.nlm.nih.gov/pubmed/32260376
http://dx.doi.org/10.3390/s20072029
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author Pelicano, Ana Catarina
Conceição, Raquel C.
author_facet Pelicano, Ana Catarina
Conceição, Raquel C.
author_sort Pelicano, Ana Catarina
collection PubMed
description The development of 3D anthropomorphic head and neck phantoms is of crucial and timely importance to explore novel imaging techniques, such as radar-based MicroWave Imaging (MWI), which have the potential to accurately diagnose Cervical Lymph Nodes (CLNs) in a neoadjuvant and non-invasive manner. We are motivated by a significant diagnostic blind-spot regarding mass screening of LNs in the case of head and neck cancer. The timely detection and selective removal of metastatic CLNs will prevent tumor cells from entering the lymphatic and blood systems and metastasizing to other body regions. The present paper describes the developed phantom generator which allows the anthropomorphic modelling of the main biological tissues of the cervical region, including CLNs, as well as their dielectric properties, for a frequency range from 1 to 10 GHz, based on Magnetic Resonance images. The resulting phantoms of varying complexity are well-suited to contribute to all stages of the development of a radar-based MWI device capable of detecting CLNs. Simpler models are essential since complexity could hinder the initial development stages of MWI devices. Besides, the diversity of anthropomorphic phantoms resulting from the developed phantom generator can be explored in other scientific contexts and may be useful to other medical imaging modalities.
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spelling pubmed-71807002020-05-01 Development of a 3D Anthropomorphic Phantom Generator for Microwave Imaging Applications of the Head and Neck Region Pelicano, Ana Catarina Conceição, Raquel C. Sensors (Basel) Article The development of 3D anthropomorphic head and neck phantoms is of crucial and timely importance to explore novel imaging techniques, such as radar-based MicroWave Imaging (MWI), which have the potential to accurately diagnose Cervical Lymph Nodes (CLNs) in a neoadjuvant and non-invasive manner. We are motivated by a significant diagnostic blind-spot regarding mass screening of LNs in the case of head and neck cancer. The timely detection and selective removal of metastatic CLNs will prevent tumor cells from entering the lymphatic and blood systems and metastasizing to other body regions. The present paper describes the developed phantom generator which allows the anthropomorphic modelling of the main biological tissues of the cervical region, including CLNs, as well as their dielectric properties, for a frequency range from 1 to 10 GHz, based on Magnetic Resonance images. The resulting phantoms of varying complexity are well-suited to contribute to all stages of the development of a radar-based MWI device capable of detecting CLNs. Simpler models are essential since complexity could hinder the initial development stages of MWI devices. Besides, the diversity of anthropomorphic phantoms resulting from the developed phantom generator can be explored in other scientific contexts and may be useful to other medical imaging modalities. MDPI 2020-04-04 /pmc/articles/PMC7180700/ /pubmed/32260376 http://dx.doi.org/10.3390/s20072029 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pelicano, Ana Catarina
Conceição, Raquel C.
Development of a 3D Anthropomorphic Phantom Generator for Microwave Imaging Applications of the Head and Neck Region
title Development of a 3D Anthropomorphic Phantom Generator for Microwave Imaging Applications of the Head and Neck Region
title_full Development of a 3D Anthropomorphic Phantom Generator for Microwave Imaging Applications of the Head and Neck Region
title_fullStr Development of a 3D Anthropomorphic Phantom Generator for Microwave Imaging Applications of the Head and Neck Region
title_full_unstemmed Development of a 3D Anthropomorphic Phantom Generator for Microwave Imaging Applications of the Head and Neck Region
title_short Development of a 3D Anthropomorphic Phantom Generator for Microwave Imaging Applications of the Head and Neck Region
title_sort development of a 3d anthropomorphic phantom generator for microwave imaging applications of the head and neck region
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180700/
https://www.ncbi.nlm.nih.gov/pubmed/32260376
http://dx.doi.org/10.3390/s20072029
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