Cargando…
Thiol-Reactive PODS-Bearing Bifunctional Chelators for the Development of EGFR-Targeting [(18)F]AlF-Affibody Conjugates
Site-selective bioconjugation of cysteine-containing peptides and proteins is currently achieved via a maleimide–thiol reaction (Michael addition). When maleimide-functionalized chelators are used and the resulting bioconjugates are subsequently radiolabeled, instability has been observed both durin...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180749/ https://www.ncbi.nlm.nih.gov/pubmed/32235296 http://dx.doi.org/10.3390/molecules25071562 |