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Lecithin-Based Dermal Drug Delivery for Anti-Pigmentation Maize Ceramide
Ceramides have several well-known biological properties, including anti-pigmentation and anti-melanogenesis, which make them applicable for use in skincare products in cosmetics. However, the efficacy of ceramides is still limited. Dermal or transdermal drug delivery systems can enhance the anti-pig...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180834/ https://www.ncbi.nlm.nih.gov/pubmed/32244349 http://dx.doi.org/10.3390/molecules25071595 |
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author | Kagotani, Kazuhiro Nakayama, Hiroko Zang, Liqing Fujimoto, Yuki Hayashi, Akihito Sono, Ryoji Nishimura, Norihiro Shimada, Yasuhito |
author_facet | Kagotani, Kazuhiro Nakayama, Hiroko Zang, Liqing Fujimoto, Yuki Hayashi, Akihito Sono, Ryoji Nishimura, Norihiro Shimada, Yasuhito |
author_sort | Kagotani, Kazuhiro |
collection | PubMed |
description | Ceramides have several well-known biological properties, including anti-pigmentation and anti-melanogenesis, which make them applicable for use in skincare products in cosmetics. However, the efficacy of ceramides is still limited. Dermal or transdermal drug delivery systems can enhance the anti-pigmentation properties of ceramides, although there is currently no systemic evaluation method for the efficacy of these systems. Here we prepared several types of lecithin-based emulsion of maize-derived glucosylceramide, determining PC70-ceramide (phosphatidylcholine-base) to be the safest and most effective anti-pigmentation agent using zebrafish larvae. We also demonstrated the efficacy of PC70 as a drug delivery system by showing that PC70-Nile Red (red fluorescence) promoted Nile Red accumulation in the larval bodies. In addition, PC70-ceramide suppressed melanin in mouse B16 melanoma cells compared to ceramide alone. In conclusion, we developed a lecithin-based dermal delivery method for ceramide using zebrafish larvae with implications for human clinical use. |
format | Online Article Text |
id | pubmed-7180834 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71808342020-05-01 Lecithin-Based Dermal Drug Delivery for Anti-Pigmentation Maize Ceramide Kagotani, Kazuhiro Nakayama, Hiroko Zang, Liqing Fujimoto, Yuki Hayashi, Akihito Sono, Ryoji Nishimura, Norihiro Shimada, Yasuhito Molecules Article Ceramides have several well-known biological properties, including anti-pigmentation and anti-melanogenesis, which make them applicable for use in skincare products in cosmetics. However, the efficacy of ceramides is still limited. Dermal or transdermal drug delivery systems can enhance the anti-pigmentation properties of ceramides, although there is currently no systemic evaluation method for the efficacy of these systems. Here we prepared several types of lecithin-based emulsion of maize-derived glucosylceramide, determining PC70-ceramide (phosphatidylcholine-base) to be the safest and most effective anti-pigmentation agent using zebrafish larvae. We also demonstrated the efficacy of PC70 as a drug delivery system by showing that PC70-Nile Red (red fluorescence) promoted Nile Red accumulation in the larval bodies. In addition, PC70-ceramide suppressed melanin in mouse B16 melanoma cells compared to ceramide alone. In conclusion, we developed a lecithin-based dermal delivery method for ceramide using zebrafish larvae with implications for human clinical use. MDPI 2020-03-31 /pmc/articles/PMC7180834/ /pubmed/32244349 http://dx.doi.org/10.3390/molecules25071595 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kagotani, Kazuhiro Nakayama, Hiroko Zang, Liqing Fujimoto, Yuki Hayashi, Akihito Sono, Ryoji Nishimura, Norihiro Shimada, Yasuhito Lecithin-Based Dermal Drug Delivery for Anti-Pigmentation Maize Ceramide |
title | Lecithin-Based Dermal Drug Delivery for Anti-Pigmentation Maize Ceramide |
title_full | Lecithin-Based Dermal Drug Delivery for Anti-Pigmentation Maize Ceramide |
title_fullStr | Lecithin-Based Dermal Drug Delivery for Anti-Pigmentation Maize Ceramide |
title_full_unstemmed | Lecithin-Based Dermal Drug Delivery for Anti-Pigmentation Maize Ceramide |
title_short | Lecithin-Based Dermal Drug Delivery for Anti-Pigmentation Maize Ceramide |
title_sort | lecithin-based dermal drug delivery for anti-pigmentation maize ceramide |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180834/ https://www.ncbi.nlm.nih.gov/pubmed/32244349 http://dx.doi.org/10.3390/molecules25071595 |
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