Antibacterial and Antifungal Sesquiterpenoids from Aerial Parts of Anvillea garcinii

Two new sesquiterpenoids belonging to the guaiane, 4α,9α,10α-trihydroxyguaia-11(13)en-12,6α-olide (1), and germacrane, 9β-hydroxyparthenolide-9-O-β-D-glucopyranoside (2), classes have been isolated from the leaves of the Saudi medicinal plant Anvillea garcinii along with seven known compounds (3–9)....

Descripción completa

Detalles Bibliográficos
Autores principales: Perveen, Shagufta, Alqahtani, Jawaher, Orfali, Raha, Aati, Hanan Y., Al-Taweel, Areej M., Ibrahim, Taghreed A., Khan, Afsar, Yusufoglu, Hasan S., Abdel-Kader, Maged S., Taglialatela-Scafati, Orazio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180898/
https://www.ncbi.nlm.nih.gov/pubmed/32283756
http://dx.doi.org/10.3390/molecules25071730
Descripción
Sumario:Two new sesquiterpenoids belonging to the guaiane, 4α,9α,10α-trihydroxyguaia-11(13)en-12,6α-olide (1), and germacrane, 9β-hydroxyparthenolide-9-O-β-D-glucopyranoside (2), classes have been isolated from the leaves of the Saudi medicinal plant Anvillea garcinii along with seven known compounds (3–9). The structures of the new metabolites were elucidated by spectroscopic analysis, including one-dimensional (1D) and two-dimensional (2D) Nuclear Magnetic Resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HR-ESIMS). The antimicrobial properties of 1–9 were screened against seven different pathogenic microbes, and compounds 1–3 showed a potent antifungal activity.

Ejemplares similares