Antibacterial and Antifungal Sesquiterpenoids from Aerial Parts of Anvillea garcinii

Two new sesquiterpenoids belonging to the guaiane, 4α,9α,10α-trihydroxyguaia-11(13)en-12,6α-olide (1), and germacrane, 9β-hydroxyparthenolide-9-O-β-D-glucopyranoside (2), classes have been isolated from the leaves of the Saudi medicinal plant Anvillea garcinii along with seven known compounds (3–9)....

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Autores principales: Perveen, Shagufta, Alqahtani, Jawaher, Orfali, Raha, Aati, Hanan Y., Al-Taweel, Areej M., Ibrahim, Taghreed A., Khan, Afsar, Yusufoglu, Hasan S., Abdel-Kader, Maged S., Taglialatela-Scafati, Orazio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180898/
https://www.ncbi.nlm.nih.gov/pubmed/32283756
http://dx.doi.org/10.3390/molecules25071730
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author Perveen, Shagufta
Alqahtani, Jawaher
Orfali, Raha
Aati, Hanan Y.
Al-Taweel, Areej M.
Ibrahim, Taghreed A.
Khan, Afsar
Yusufoglu, Hasan S.
Abdel-Kader, Maged S.
Taglialatela-Scafati, Orazio
author_facet Perveen, Shagufta
Alqahtani, Jawaher
Orfali, Raha
Aati, Hanan Y.
Al-Taweel, Areej M.
Ibrahim, Taghreed A.
Khan, Afsar
Yusufoglu, Hasan S.
Abdel-Kader, Maged S.
Taglialatela-Scafati, Orazio
author_sort Perveen, Shagufta
collection PubMed
description Two new sesquiterpenoids belonging to the guaiane, 4α,9α,10α-trihydroxyguaia-11(13)en-12,6α-olide (1), and germacrane, 9β-hydroxyparthenolide-9-O-β-D-glucopyranoside (2), classes have been isolated from the leaves of the Saudi medicinal plant Anvillea garcinii along with seven known compounds (3–9). The structures of the new metabolites were elucidated by spectroscopic analysis, including one-dimensional (1D) and two-dimensional (2D) Nuclear Magnetic Resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HR-ESIMS). The antimicrobial properties of 1–9 were screened against seven different pathogenic microbes, and compounds 1–3 showed a potent antifungal activity.
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spelling pubmed-71808982020-05-01 Antibacterial and Antifungal Sesquiterpenoids from Aerial Parts of Anvillea garcinii Perveen, Shagufta Alqahtani, Jawaher Orfali, Raha Aati, Hanan Y. Al-Taweel, Areej M. Ibrahim, Taghreed A. Khan, Afsar Yusufoglu, Hasan S. Abdel-Kader, Maged S. Taglialatela-Scafati, Orazio Molecules Article Two new sesquiterpenoids belonging to the guaiane, 4α,9α,10α-trihydroxyguaia-11(13)en-12,6α-olide (1), and germacrane, 9β-hydroxyparthenolide-9-O-β-D-glucopyranoside (2), classes have been isolated from the leaves of the Saudi medicinal plant Anvillea garcinii along with seven known compounds (3–9). The structures of the new metabolites were elucidated by spectroscopic analysis, including one-dimensional (1D) and two-dimensional (2D) Nuclear Magnetic Resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HR-ESIMS). The antimicrobial properties of 1–9 were screened against seven different pathogenic microbes, and compounds 1–3 showed a potent antifungal activity. MDPI 2020-04-09 /pmc/articles/PMC7180898/ /pubmed/32283756 http://dx.doi.org/10.3390/molecules25071730 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Perveen, Shagufta
Alqahtani, Jawaher
Orfali, Raha
Aati, Hanan Y.
Al-Taweel, Areej M.
Ibrahim, Taghreed A.
Khan, Afsar
Yusufoglu, Hasan S.
Abdel-Kader, Maged S.
Taglialatela-Scafati, Orazio
Antibacterial and Antifungal Sesquiterpenoids from Aerial Parts of Anvillea garcinii
title Antibacterial and Antifungal Sesquiterpenoids from Aerial Parts of Anvillea garcinii
title_full Antibacterial and Antifungal Sesquiterpenoids from Aerial Parts of Anvillea garcinii
title_fullStr Antibacterial and Antifungal Sesquiterpenoids from Aerial Parts of Anvillea garcinii
title_full_unstemmed Antibacterial and Antifungal Sesquiterpenoids from Aerial Parts of Anvillea garcinii
title_short Antibacterial and Antifungal Sesquiterpenoids from Aerial Parts of Anvillea garcinii
title_sort antibacterial and antifungal sesquiterpenoids from aerial parts of anvillea garcinii
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180898/
https://www.ncbi.nlm.nih.gov/pubmed/32283756
http://dx.doi.org/10.3390/molecules25071730
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