Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivatives

Novel triazole-porphyrin derivatives (TZ-PORs) were synthesized through the Heck reaction and then incorporated into polyvinylpyrrolidone (PVP) micelles. After verifying that this incorporation did not compromise the photophysical and chemical features of TZ-PORs as photosensitizers, the phototoxici...

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Autores principales: Gomes, Ana T. P. C., Fernandes, Rosa, Ribeiro, Carlos F., Tomé, João P. C., Neves, Maria G. P. M. S., da Silva, Fernando de C., Ferreira, Vítor F., Cavaleiro, José A. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180931/
https://www.ncbi.nlm.nih.gov/pubmed/32244514
http://dx.doi.org/10.3390/molecules25071607
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author Gomes, Ana T. P. C.
Fernandes, Rosa
Ribeiro, Carlos F.
Tomé, João P. C.
Neves, Maria G. P. M. S.
da Silva, Fernando de C.
Ferreira, Vítor F.
Cavaleiro, José A. S.
author_facet Gomes, Ana T. P. C.
Fernandes, Rosa
Ribeiro, Carlos F.
Tomé, João P. C.
Neves, Maria G. P. M. S.
da Silva, Fernando de C.
Ferreira, Vítor F.
Cavaleiro, José A. S.
author_sort Gomes, Ana T. P. C.
collection PubMed
description Novel triazole-porphyrin derivatives (TZ-PORs) were synthesized through the Heck reaction and then incorporated into polyvinylpyrrolidone (PVP) micelles. After verifying that this incorporation did not compromise the photophysical and chemical features of TZ-PORs as photosensitizers, the phototoxicity of the formulations towards cancer cells was screened. Biological studies show high photodynamic activity of all PVP-TZ-POR formulations against a bladder cancer cell line with a particular highlight to PVP-TZ-POR 7e and 7f that are able to significantly reduce HT-1376 cell viability, while they had no effect on control ARPE-19 cells.
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spelling pubmed-71809312020-04-30 Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivatives Gomes, Ana T. P. C. Fernandes, Rosa Ribeiro, Carlos F. Tomé, João P. C. Neves, Maria G. P. M. S. da Silva, Fernando de C. Ferreira, Vítor F. Cavaleiro, José A. S. Molecules Article Novel triazole-porphyrin derivatives (TZ-PORs) were synthesized through the Heck reaction and then incorporated into polyvinylpyrrolidone (PVP) micelles. After verifying that this incorporation did not compromise the photophysical and chemical features of TZ-PORs as photosensitizers, the phototoxicity of the formulations towards cancer cells was screened. Biological studies show high photodynamic activity of all PVP-TZ-POR formulations against a bladder cancer cell line with a particular highlight to PVP-TZ-POR 7e and 7f that are able to significantly reduce HT-1376 cell viability, while they had no effect on control ARPE-19 cells. MDPI 2020-03-31 /pmc/articles/PMC7180931/ /pubmed/32244514 http://dx.doi.org/10.3390/molecules25071607 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gomes, Ana T. P. C.
Fernandes, Rosa
Ribeiro, Carlos F.
Tomé, João P. C.
Neves, Maria G. P. M. S.
da Silva, Fernando de C.
Ferreira, Vítor F.
Cavaleiro, José A. S.
Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivatives
title Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivatives
title_full Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivatives
title_fullStr Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivatives
title_full_unstemmed Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivatives
title_short Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivatives
title_sort synthesis, characterization and photodynamic activity against bladder cancer cells of novel triazole-porphyrin derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180931/
https://www.ncbi.nlm.nih.gov/pubmed/32244514
http://dx.doi.org/10.3390/molecules25071607
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