An Efficient Metal-Free Oxidative Esterification and Amination of Benzyl C–H Bond

An esterification and amination of benzylic C–H bonds was developed by using 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) under metal- and iodide-free conditions. Both carboxylic acids and amines could be used as ideal coupling partners for the oxidative coupling reactions with various diarylmeth...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Saiwen, Chen, Ru, He, Guowen, Zhang, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180972/
https://www.ncbi.nlm.nih.gov/pubmed/32230851
http://dx.doi.org/10.3390/molecules25071527
Descripción
Sumario:An esterification and amination of benzylic C–H bonds was developed by using 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) under metal- and iodide-free conditions. Both carboxylic acids and amines could be used as ideal coupling partners for the oxidative coupling reactions with various diarylmethanes. A close to equal amount of coupling reagents was enough to afford the product in good to high yields.

Ejemplares similares