An Efficient Metal-Free Oxidative Esterification and Amination of Benzyl C–H Bond

An esterification and amination of benzylic C–H bonds was developed by using 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) under metal- and iodide-free conditions. Both carboxylic acids and amines could be used as ideal coupling partners for the oxidative coupling reactions with various diarylmeth...

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Detalles Bibliográficos
Autores principales: Liu, Saiwen, Chen, Ru, He, Guowen, Zhang, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180972/
https://www.ncbi.nlm.nih.gov/pubmed/32230851
http://dx.doi.org/10.3390/molecules25071527
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author Liu, Saiwen
Chen, Ru
He, Guowen
Zhang, Jin
author_facet Liu, Saiwen
Chen, Ru
He, Guowen
Zhang, Jin
author_sort Liu, Saiwen
collection PubMed
description An esterification and amination of benzylic C–H bonds was developed by using 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) under metal- and iodide-free conditions. Both carboxylic acids and amines could be used as ideal coupling partners for the oxidative coupling reactions with various diarylmethanes. A close to equal amount of coupling reagents was enough to afford the product in good to high yields.
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spelling pubmed-71809722020-04-30 An Efficient Metal-Free Oxidative Esterification and Amination of Benzyl C–H Bond Liu, Saiwen Chen, Ru He, Guowen Zhang, Jin Molecules Communication An esterification and amination of benzylic C–H bonds was developed by using 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) under metal- and iodide-free conditions. Both carboxylic acids and amines could be used as ideal coupling partners for the oxidative coupling reactions with various diarylmethanes. A close to equal amount of coupling reagents was enough to afford the product in good to high yields. MDPI 2020-03-27 /pmc/articles/PMC7180972/ /pubmed/32230851 http://dx.doi.org/10.3390/molecules25071527 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Liu, Saiwen
Chen, Ru
He, Guowen
Zhang, Jin
An Efficient Metal-Free Oxidative Esterification and Amination of Benzyl C–H Bond
title An Efficient Metal-Free Oxidative Esterification and Amination of Benzyl C–H Bond
title_full An Efficient Metal-Free Oxidative Esterification and Amination of Benzyl C–H Bond
title_fullStr An Efficient Metal-Free Oxidative Esterification and Amination of Benzyl C–H Bond
title_full_unstemmed An Efficient Metal-Free Oxidative Esterification and Amination of Benzyl C–H Bond
title_short An Efficient Metal-Free Oxidative Esterification and Amination of Benzyl C–H Bond
title_sort efficient metal-free oxidative esterification and amination of benzyl c–h bond
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180972/
https://www.ncbi.nlm.nih.gov/pubmed/32230851
http://dx.doi.org/10.3390/molecules25071527
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