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Subchronic Toxicity of the New Iodine Complex in Dogs and Rats

Background: Complexes of iodine (povidone-iodine and cadexomers) are among the most important antiseptics used in clinical and veterinary medicines. However, high local irritation activity and systemic toxicity limits their oral administration. The purpose of the study was to compare the effect of a...

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Autores principales: Islamov, Rinat, Kustova, Tatyana, Nersesyan, Armen, Ilin, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181231/
https://www.ncbi.nlm.nih.gov/pubmed/32363201
http://dx.doi.org/10.3389/fvets.2020.00184
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author Islamov, Rinat
Kustova, Tatyana
Nersesyan, Armen
Ilin, Alexander
author_facet Islamov, Rinat
Kustova, Tatyana
Nersesyan, Armen
Ilin, Alexander
author_sort Islamov, Rinat
collection PubMed
description Background: Complexes of iodine (povidone-iodine and cadexomers) are among the most important antiseptics used in clinical and veterinary medicines. However, high local irritation activity and systemic toxicity limits their oral administration. The purpose of the study was to compare the effect of a new complex of iodine (PA, potentiator of anticancer antibiotics), in which iodine is coordinated by carbohydrates and polypeptides) on the organisms of rats and dogs treated orally with the drug for 30 days. Methods: Wistar rats and Beagle dogs served as experimental animal models. Effect of PA on the animal organism was examined through the measurements of hormones level changes, hematological and clinical chemistry parameters alterations, necropsy and histological examination. Results: The established maximum tolerated dose (MTD) of 2,000 mg/kg PA led to a decrease in the rate of body weight gain in male and female rats. Changes in hematological and certain biochemical parameters in rats at doses of 1,000 and 2,000 mg/kg were observed. Histological study of the thyroid gland revealed changes in the shape and size of the follicles along with colloid resorption. Administration of a half of MTD (180 mg/kg) and lower doses did not result in any change in dogs (thyroid-stimulating hormone, triiodothyronine, and thyroxine). Conclusions: The results of our study show that the pathogenetic action of PA takes place along the path of induction of an inflammatory response with the development of thyrotoxicosis, rather than hypothyroidism. The mechanism of induction of an inflammatory response is also confirmed by histological studies of lesions of the thyroid gland and testes in rats (Figure S1). The no-observed-adverse-effect level (NOAEL) of PA is estimated to be 180 mg/kg (or iodine 22.8 mg/kg) in dogs, which is equivalent to 100 mg/kg (or iodine 12.3 mg/kg) in humans.
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spelling pubmed-71812312020-05-01 Subchronic Toxicity of the New Iodine Complex in Dogs and Rats Islamov, Rinat Kustova, Tatyana Nersesyan, Armen Ilin, Alexander Front Vet Sci Veterinary Science Background: Complexes of iodine (povidone-iodine and cadexomers) are among the most important antiseptics used in clinical and veterinary medicines. However, high local irritation activity and systemic toxicity limits their oral administration. The purpose of the study was to compare the effect of a new complex of iodine (PA, potentiator of anticancer antibiotics), in which iodine is coordinated by carbohydrates and polypeptides) on the organisms of rats and dogs treated orally with the drug for 30 days. Methods: Wistar rats and Beagle dogs served as experimental animal models. Effect of PA on the animal organism was examined through the measurements of hormones level changes, hematological and clinical chemistry parameters alterations, necropsy and histological examination. Results: The established maximum tolerated dose (MTD) of 2,000 mg/kg PA led to a decrease in the rate of body weight gain in male and female rats. Changes in hematological and certain biochemical parameters in rats at doses of 1,000 and 2,000 mg/kg were observed. Histological study of the thyroid gland revealed changes in the shape and size of the follicles along with colloid resorption. Administration of a half of MTD (180 mg/kg) and lower doses did not result in any change in dogs (thyroid-stimulating hormone, triiodothyronine, and thyroxine). Conclusions: The results of our study show that the pathogenetic action of PA takes place along the path of induction of an inflammatory response with the development of thyrotoxicosis, rather than hypothyroidism. The mechanism of induction of an inflammatory response is also confirmed by histological studies of lesions of the thyroid gland and testes in rats (Figure S1). The no-observed-adverse-effect level (NOAEL) of PA is estimated to be 180 mg/kg (or iodine 22.8 mg/kg) in dogs, which is equivalent to 100 mg/kg (or iodine 12.3 mg/kg) in humans. Frontiers Media S.A. 2020-04-17 /pmc/articles/PMC7181231/ /pubmed/32363201 http://dx.doi.org/10.3389/fvets.2020.00184 Text en Copyright © 2020 Islamov, Kustova, Nersesyan and Ilin. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Islamov, Rinat
Kustova, Tatyana
Nersesyan, Armen
Ilin, Alexander
Subchronic Toxicity of the New Iodine Complex in Dogs and Rats
title Subchronic Toxicity of the New Iodine Complex in Dogs and Rats
title_full Subchronic Toxicity of the New Iodine Complex in Dogs and Rats
title_fullStr Subchronic Toxicity of the New Iodine Complex in Dogs and Rats
title_full_unstemmed Subchronic Toxicity of the New Iodine Complex in Dogs and Rats
title_short Subchronic Toxicity of the New Iodine Complex in Dogs and Rats
title_sort subchronic toxicity of the new iodine complex in dogs and rats
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181231/
https://www.ncbi.nlm.nih.gov/pubmed/32363201
http://dx.doi.org/10.3389/fvets.2020.00184
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