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Population genetics of 30 insertion/deletion polymorphisms in the Kuwaiti population

This study evaluates the forensic utility of the 30 insertion and deletion (indel) markers contained in the Qiagen Investigator® DIPplex kit in the Kuwaiti population (n = 150). All but one of the 30 markers were shown to conform to the expectations of the Hardy-Weinberg Equilibrium. Linkage disequi...

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Detalles Bibliográficos
Autores principales: Haidar, Mahdi, Alsaleh, Hussain, Haddrill, Penelope R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181444/
https://www.ncbi.nlm.nih.gov/pubmed/31728633
http://dx.doi.org/10.1007/s00414-019-02180-4
Descripción
Sumario:This study evaluates the forensic utility of the 30 insertion and deletion (indel) markers contained in the Qiagen Investigator® DIPplex kit in the Kuwaiti population (n = 150). All but one of the 30 markers were shown to conform to the expectations of the Hardy-Weinberg Equilibrium. Linkage disequilibrium tests showed no statistically significant deviation from independence. The high combined power of discrimination (CPD > 99.999%) and low combined match probability (CMP) of 2.736 × 10(−13) provide a satisfactory level of discrimination, allowing the DIPplex loci to be used as forensic markers for individual identification in Kuwait. The paternity indices indicate the usefulness of the DIPplex kit as a supplementary typing system for challenging paternity cases in Kuwait. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00414-019-02180-4) contains supplementary material, which is available to authorized users.