Cargando…
Population genetics of 30 insertion/deletion polymorphisms in the Kuwaiti population
This study evaluates the forensic utility of the 30 insertion and deletion (indel) markers contained in the Qiagen Investigator® DIPplex kit in the Kuwaiti population (n = 150). All but one of the 30 markers were shown to conform to the expectations of the Hardy-Weinberg Equilibrium. Linkage disequi...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181444/ https://www.ncbi.nlm.nih.gov/pubmed/31728633 http://dx.doi.org/10.1007/s00414-019-02180-4 |
_version_ | 1783526041688473600 |
---|---|
author | Haidar, Mahdi Alsaleh, Hussain Haddrill, Penelope R. |
author_facet | Haidar, Mahdi Alsaleh, Hussain Haddrill, Penelope R. |
author_sort | Haidar, Mahdi |
collection | PubMed |
description | This study evaluates the forensic utility of the 30 insertion and deletion (indel) markers contained in the Qiagen Investigator® DIPplex kit in the Kuwaiti population (n = 150). All but one of the 30 markers were shown to conform to the expectations of the Hardy-Weinberg Equilibrium. Linkage disequilibrium tests showed no statistically significant deviation from independence. The high combined power of discrimination (CPD > 99.999%) and low combined match probability (CMP) of 2.736 × 10(−13) provide a satisfactory level of discrimination, allowing the DIPplex loci to be used as forensic markers for individual identification in Kuwait. The paternity indices indicate the usefulness of the DIPplex kit as a supplementary typing system for challenging paternity cases in Kuwait. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00414-019-02180-4) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-7181444 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-71814442020-04-29 Population genetics of 30 insertion/deletion polymorphisms in the Kuwaiti population Haidar, Mahdi Alsaleh, Hussain Haddrill, Penelope R. Int J Legal Med Population Data This study evaluates the forensic utility of the 30 insertion and deletion (indel) markers contained in the Qiagen Investigator® DIPplex kit in the Kuwaiti population (n = 150). All but one of the 30 markers were shown to conform to the expectations of the Hardy-Weinberg Equilibrium. Linkage disequilibrium tests showed no statistically significant deviation from independence. The high combined power of discrimination (CPD > 99.999%) and low combined match probability (CMP) of 2.736 × 10(−13) provide a satisfactory level of discrimination, allowing the DIPplex loci to be used as forensic markers for individual identification in Kuwait. The paternity indices indicate the usefulness of the DIPplex kit as a supplementary typing system for challenging paternity cases in Kuwait. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00414-019-02180-4) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2019-11-14 2020 /pmc/articles/PMC7181444/ /pubmed/31728633 http://dx.doi.org/10.1007/s00414-019-02180-4 Text en © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Population Data Haidar, Mahdi Alsaleh, Hussain Haddrill, Penelope R. Population genetics of 30 insertion/deletion polymorphisms in the Kuwaiti population |
title | Population genetics of 30 insertion/deletion polymorphisms in the Kuwaiti population |
title_full | Population genetics of 30 insertion/deletion polymorphisms in the Kuwaiti population |
title_fullStr | Population genetics of 30 insertion/deletion polymorphisms in the Kuwaiti population |
title_full_unstemmed | Population genetics of 30 insertion/deletion polymorphisms in the Kuwaiti population |
title_short | Population genetics of 30 insertion/deletion polymorphisms in the Kuwaiti population |
title_sort | population genetics of 30 insertion/deletion polymorphisms in the kuwaiti population |
topic | Population Data |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181444/ https://www.ncbi.nlm.nih.gov/pubmed/31728633 http://dx.doi.org/10.1007/s00414-019-02180-4 |
work_keys_str_mv | AT haidarmahdi populationgeneticsof30insertiondeletionpolymorphismsinthekuwaitipopulation AT alsalehhussain populationgeneticsof30insertiondeletionpolymorphismsinthekuwaitipopulation AT haddrillpeneloper populationgeneticsof30insertiondeletionpolymorphismsinthekuwaitipopulation |