Cargando…

Population genetics of 30 insertion/deletion polymorphisms in the Kuwaiti population

This study evaluates the forensic utility of the 30 insertion and deletion (indel) markers contained in the Qiagen Investigator® DIPplex kit in the Kuwaiti population (n = 150). All but one of the 30 markers were shown to conform to the expectations of the Hardy-Weinberg Equilibrium. Linkage disequi...

Descripción completa

Detalles Bibliográficos
Autores principales: Haidar, Mahdi, Alsaleh, Hussain, Haddrill, Penelope R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181444/
https://www.ncbi.nlm.nih.gov/pubmed/31728633
http://dx.doi.org/10.1007/s00414-019-02180-4
_version_ 1783526041688473600
author Haidar, Mahdi
Alsaleh, Hussain
Haddrill, Penelope R.
author_facet Haidar, Mahdi
Alsaleh, Hussain
Haddrill, Penelope R.
author_sort Haidar, Mahdi
collection PubMed
description This study evaluates the forensic utility of the 30 insertion and deletion (indel) markers contained in the Qiagen Investigator® DIPplex kit in the Kuwaiti population (n = 150). All but one of the 30 markers were shown to conform to the expectations of the Hardy-Weinberg Equilibrium. Linkage disequilibrium tests showed no statistically significant deviation from independence. The high combined power of discrimination (CPD > 99.999%) and low combined match probability (CMP) of 2.736 × 10(−13) provide a satisfactory level of discrimination, allowing the DIPplex loci to be used as forensic markers for individual identification in Kuwait. The paternity indices indicate the usefulness of the DIPplex kit as a supplementary typing system for challenging paternity cases in Kuwait. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00414-019-02180-4) contains supplementary material, which is available to authorized users.
format Online
Article
Text
id pubmed-7181444
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-71814442020-04-29 Population genetics of 30 insertion/deletion polymorphisms in the Kuwaiti population Haidar, Mahdi Alsaleh, Hussain Haddrill, Penelope R. Int J Legal Med Population Data This study evaluates the forensic utility of the 30 insertion and deletion (indel) markers contained in the Qiagen Investigator® DIPplex kit in the Kuwaiti population (n = 150). All but one of the 30 markers were shown to conform to the expectations of the Hardy-Weinberg Equilibrium. Linkage disequilibrium tests showed no statistically significant deviation from independence. The high combined power of discrimination (CPD > 99.999%) and low combined match probability (CMP) of 2.736 × 10(−13) provide a satisfactory level of discrimination, allowing the DIPplex loci to be used as forensic markers for individual identification in Kuwait. The paternity indices indicate the usefulness of the DIPplex kit as a supplementary typing system for challenging paternity cases in Kuwait. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00414-019-02180-4) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2019-11-14 2020 /pmc/articles/PMC7181444/ /pubmed/31728633 http://dx.doi.org/10.1007/s00414-019-02180-4 Text en © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Population Data
Haidar, Mahdi
Alsaleh, Hussain
Haddrill, Penelope R.
Population genetics of 30 insertion/deletion polymorphisms in the Kuwaiti population
title Population genetics of 30 insertion/deletion polymorphisms in the Kuwaiti population
title_full Population genetics of 30 insertion/deletion polymorphisms in the Kuwaiti population
title_fullStr Population genetics of 30 insertion/deletion polymorphisms in the Kuwaiti population
title_full_unstemmed Population genetics of 30 insertion/deletion polymorphisms in the Kuwaiti population
title_short Population genetics of 30 insertion/deletion polymorphisms in the Kuwaiti population
title_sort population genetics of 30 insertion/deletion polymorphisms in the kuwaiti population
topic Population Data
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181444/
https://www.ncbi.nlm.nih.gov/pubmed/31728633
http://dx.doi.org/10.1007/s00414-019-02180-4
work_keys_str_mv AT haidarmahdi populationgeneticsof30insertiondeletionpolymorphismsinthekuwaitipopulation
AT alsalehhussain populationgeneticsof30insertiondeletionpolymorphismsinthekuwaitipopulation
AT haddrillpeneloper populationgeneticsof30insertiondeletionpolymorphismsinthekuwaitipopulation