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A vaccine-based nanosystem for initiating innate immunity and improving tumor immunotherapy

The unsatisfactory response rate of immune checkpoint blockade (ICB) immunotherapy severely limits its clinical application as a tumor therapy. Here, we generate a vaccine-based nanosystem by integrating siRNA for Cd274 into the commercial human papillomavirus (HPV) L1 (HPV16 L1) protein. This nanos...

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Detalles Bibliográficos
Autores principales:	Zheng, Di-Wei, Gao, Fan, Cheng, Qian, Bao, Peng, Dong, Xue, Fan, Jin-Xuan, Song, Wen, Zeng, Xuan, Cheng, Si-Xue, Zhang, Xian-Zheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181622/ https://www.ncbi.nlm.nih.gov/pubmed/32332752 http://dx.doi.org/10.1038/s41467-020-15927-0

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