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Development of a stereo dip-coating system for fabrication of tube-shaped blood vessel models

Tube-shaped blood vessel models that mimic their geometries and mechanical properties can deliver reliable and realistic behavioral information such as deformation and rupture during procedures such as insertion of medical devices. Thickness of vessel walls is an important parameter for fabricating...

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Autores principales: Shimizu, Yasutomo, Tupin, Simon, Kiyomitsu, Chihaya, Kitamura, Ko, Takashima, Kazuto, Ohta, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181637/
https://www.ncbi.nlm.nih.gov/pubmed/32332779
http://dx.doi.org/10.1038/s41598-020-63718-w
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author Shimizu, Yasutomo
Tupin, Simon
Kiyomitsu, Chihaya
Kitamura, Ko
Takashima, Kazuto
Ohta, Makoto
author_facet Shimizu, Yasutomo
Tupin, Simon
Kiyomitsu, Chihaya
Kitamura, Ko
Takashima, Kazuto
Ohta, Makoto
author_sort Shimizu, Yasutomo
collection PubMed
description Tube-shaped blood vessel models that mimic their geometries and mechanical properties can deliver reliable and realistic behavioral information such as deformation and rupture during procedures such as insertion of medical devices. Thickness of vessel walls is an important parameter for fabricating the blood vessel models owing to their strong influence on the model behavior, especially during deformation. The dip-coating method is used to fabricate blood vessel models; however, non-uniform wall thicknesses are observed using this method. This study aimed at finding the characteristics of stereo “angular control dip-coating” (ACDC) system to develop a dip-coating system that can produce tubular models with uniformed wall thickness. The system developed here enables an observation of the substrate behavior from two different views. The conditions of dip-coating used in this study produce 1.36–1.82 mm in the maximum and 0.188–0.435 mm in minimum wall thickness and the fabricated walls cover the realistic range of carotid arterial dimensions. The characteristics of the ACDC system indicate that ACDC is effective for fabricating the uniform wall thickness particularly in the strong curved parts.
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spelling pubmed-71816372020-04-27 Development of a stereo dip-coating system for fabrication of tube-shaped blood vessel models Shimizu, Yasutomo Tupin, Simon Kiyomitsu, Chihaya Kitamura, Ko Takashima, Kazuto Ohta, Makoto Sci Rep Article Tube-shaped blood vessel models that mimic their geometries and mechanical properties can deliver reliable and realistic behavioral information such as deformation and rupture during procedures such as insertion of medical devices. Thickness of vessel walls is an important parameter for fabricating the blood vessel models owing to their strong influence on the model behavior, especially during deformation. The dip-coating method is used to fabricate blood vessel models; however, non-uniform wall thicknesses are observed using this method. This study aimed at finding the characteristics of stereo “angular control dip-coating” (ACDC) system to develop a dip-coating system that can produce tubular models with uniformed wall thickness. The system developed here enables an observation of the substrate behavior from two different views. The conditions of dip-coating used in this study produce 1.36–1.82 mm in the maximum and 0.188–0.435 mm in minimum wall thickness and the fabricated walls cover the realistic range of carotid arterial dimensions. The characteristics of the ACDC system indicate that ACDC is effective for fabricating the uniform wall thickness particularly in the strong curved parts. Nature Publishing Group UK 2020-04-24 /pmc/articles/PMC7181637/ /pubmed/32332779 http://dx.doi.org/10.1038/s41598-020-63718-w Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Shimizu, Yasutomo
Tupin, Simon
Kiyomitsu, Chihaya
Kitamura, Ko
Takashima, Kazuto
Ohta, Makoto
Development of a stereo dip-coating system for fabrication of tube-shaped blood vessel models
title Development of a stereo dip-coating system for fabrication of tube-shaped blood vessel models
title_full Development of a stereo dip-coating system for fabrication of tube-shaped blood vessel models
title_fullStr Development of a stereo dip-coating system for fabrication of tube-shaped blood vessel models
title_full_unstemmed Development of a stereo dip-coating system for fabrication of tube-shaped blood vessel models
title_short Development of a stereo dip-coating system for fabrication of tube-shaped blood vessel models
title_sort development of a stereo dip-coating system for fabrication of tube-shaped blood vessel models
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181637/
https://www.ncbi.nlm.nih.gov/pubmed/32332779
http://dx.doi.org/10.1038/s41598-020-63718-w
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