Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis

Patients diagnosed with metastatic breast cancer have a dismal 5-year survival rate of only 24%. The RNA-binding protein Hu antigen R (HuR) is upregulated in breast cancer, and elevated cytoplasmic HuR correlates with high-grade tumors and poor clinical outcome of breast cancer. HuR promotes tumorig...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Xiaoqing, Gardashova, Gulhumay, Lan, Lan, Han, Shuang, Zhong, Cuncong, Marquez, Rebecca T., Wei, Lanjing, Wood, Spencer, Roy, Sudeshna, Gowthaman, Ragul, Karanicolas, John, Gao, Fei P., Dixon, Dan A., Welch, Danny R., Li, Ling, Ji, Min, Aubé, Jeffrey, Xu, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181695/
https://www.ncbi.nlm.nih.gov/pubmed/32332873
http://dx.doi.org/10.1038/s42003-020-0933-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181695/
https://www.ncbi.nlm.nih.gov/pubmed/32332873
http://dx.doi.org/10.1038/s42003-020-0933-1

Ejemplares similares