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Sex chromosome evolution in parasitic nematodes of humans
Sex determination mechanisms often differ even between related species yet the evolution of sex chromosomes remains poorly understood in all but a few model organisms. Some nematodes such as Caenorhabditis elegans have an XO sex determination system while others, such as the filarial parasite Brugia...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181701/ https://www.ncbi.nlm.nih.gov/pubmed/32327641 http://dx.doi.org/10.1038/s41467-020-15654-6 |
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| author | Foster, Jeremy M. Grote, Alexandra Mattick, John Tracey, Alan Tsai, Yu-Chih Chung, Matthew Cotton, James A. Clark, Tyson A. Geber, Adam Holroyd, Nancy Korlach, Jonas Li, Yichao Libro, Silvia Lustigman, Sara Michalski, Michelle L. Paulini, Michael Rogers, Matthew B. Teigen, Laura Twaddle, Alan Welch, Lonnie Berriman, Matthew Dunning Hotopp, Julie C. Ghedin, Elodie |
| author_facet | Foster, Jeremy M. Grote, Alexandra Mattick, John Tracey, Alan Tsai, Yu-Chih Chung, Matthew Cotton, James A. Clark, Tyson A. Geber, Adam Holroyd, Nancy Korlach, Jonas Li, Yichao Libro, Silvia Lustigman, Sara Michalski, Michelle L. Paulini, Michael Rogers, Matthew B. Teigen, Laura Twaddle, Alan Welch, Lonnie Berriman, Matthew Dunning Hotopp, Julie C. Ghedin, Elodie |
| author_sort | Foster, Jeremy M. |
| collection | PubMed |
| description | Sex determination mechanisms often differ even between related species yet the evolution of sex chromosomes remains poorly understood in all but a few model organisms. Some nematodes such as Caenorhabditis elegans have an XO sex determination system while others, such as the filarial parasite Brugia malayi, have an XY mechanism. We present a complete B. malayi genome assembly and define Nigon elements shared with C. elegans, which we then map to the genomes of other filarial species and more distantly related nematodes. We find a remarkable plasticity in sex chromosome evolution with several distinct cases of neo-X and neo-Y formation, X-added regions, and conversion of autosomes to sex chromosomes from which we propose a model of chromosome evolution across different nematode clades. The phylum Nematoda offers a new and innovative system for gaining a deeper understanding of sex chromosome evolution. |
| format | Online Article Text |
| id | pubmed-7181701 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-71817012020-04-29 Sex chromosome evolution in parasitic nematodes of humans Foster, Jeremy M. Grote, Alexandra Mattick, John Tracey, Alan Tsai, Yu-Chih Chung, Matthew Cotton, James A. Clark, Tyson A. Geber, Adam Holroyd, Nancy Korlach, Jonas Li, Yichao Libro, Silvia Lustigman, Sara Michalski, Michelle L. Paulini, Michael Rogers, Matthew B. Teigen, Laura Twaddle, Alan Welch, Lonnie Berriman, Matthew Dunning Hotopp, Julie C. Ghedin, Elodie Nat Commun Article Sex determination mechanisms often differ even between related species yet the evolution of sex chromosomes remains poorly understood in all but a few model organisms. Some nematodes such as Caenorhabditis elegans have an XO sex determination system while others, such as the filarial parasite Brugia malayi, have an XY mechanism. We present a complete B. malayi genome assembly and define Nigon elements shared with C. elegans, which we then map to the genomes of other filarial species and more distantly related nematodes. We find a remarkable plasticity in sex chromosome evolution with several distinct cases of neo-X and neo-Y formation, X-added regions, and conversion of autosomes to sex chromosomes from which we propose a model of chromosome evolution across different nematode clades. The phylum Nematoda offers a new and innovative system for gaining a deeper understanding of sex chromosome evolution. Nature Publishing Group UK 2020-04-23 /pmc/articles/PMC7181701/ /pubmed/32327641 http://dx.doi.org/10.1038/s41467-020-15654-6 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Article Foster, Jeremy M. Grote, Alexandra Mattick, John Tracey, Alan Tsai, Yu-Chih Chung, Matthew Cotton, James A. Clark, Tyson A. Geber, Adam Holroyd, Nancy Korlach, Jonas Li, Yichao Libro, Silvia Lustigman, Sara Michalski, Michelle L. Paulini, Michael Rogers, Matthew B. Teigen, Laura Twaddle, Alan Welch, Lonnie Berriman, Matthew Dunning Hotopp, Julie C. Ghedin, Elodie Sex chromosome evolution in parasitic nematodes of humans |
| title | Sex chromosome evolution in parasitic nematodes of humans |
| title_full | Sex chromosome evolution in parasitic nematodes of humans |
| title_fullStr | Sex chromosome evolution in parasitic nematodes of humans |
| title_full_unstemmed | Sex chromosome evolution in parasitic nematodes of humans |
| title_short | Sex chromosome evolution in parasitic nematodes of humans |
| title_sort | sex chromosome evolution in parasitic nematodes of humans |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181701/ https://www.ncbi.nlm.nih.gov/pubmed/32327641 http://dx.doi.org/10.1038/s41467-020-15654-6 |
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