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FGF21 Mimics a Fasting-Induced Metabolic State and Increases Appetite in Zebrafish

Fibroblast growth factor 21 (FGF21) is a member of the FGF superfamily that acts in an endocrine manner. FGF21 is a key regulator of energy balance and metabolism in mammals, and has emerged as a therapeutic potential for treating obesity and diabetes. Here, we report that mRNAs encoding FGF21 and i...

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Autores principales: Blanco, Ayelén Melisa, Bertucci, Juan Ignacio, Unniappan, Suraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181725/
https://www.ncbi.nlm.nih.gov/pubmed/32332781
http://dx.doi.org/10.1038/s41598-020-63726-w
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author Blanco, Ayelén Melisa
Bertucci, Juan Ignacio
Unniappan, Suraj
author_facet Blanco, Ayelén Melisa
Bertucci, Juan Ignacio
Unniappan, Suraj
author_sort Blanco, Ayelén Melisa
collection PubMed
description Fibroblast growth factor 21 (FGF21) is a member of the FGF superfamily that acts in an endocrine manner. FGF21 is a key regulator of energy balance and metabolism in mammals, and has emerged as a therapeutic potential for treating obesity and diabetes. Here, we report that mRNAs encoding FGF21 and its receptors are widely distributed within the zebrafish tissues and are importantly modulated by fasting (decreased in brain and liver, and increased in gut). FGF21 stimulates food intake in zebrafish, likely in part by modulating brain npy/agrp and nucb2/nesfatin-1 and gut ghrelin and cck mRNA expression. In accordance with this orexigenic role, the expression of FGF21 and its receptors were observed to increase preprandially and decrease post-feeding in the foregut and/or liver. Finally, we found important evidence in favor of a role for FGF21 in regulating glucose and lipid metabolism in the zebrafish liver in a way that mimics a fasting metabolic state.
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spelling pubmed-71817252020-04-29 FGF21 Mimics a Fasting-Induced Metabolic State and Increases Appetite in Zebrafish Blanco, Ayelén Melisa Bertucci, Juan Ignacio Unniappan, Suraj Sci Rep Article Fibroblast growth factor 21 (FGF21) is a member of the FGF superfamily that acts in an endocrine manner. FGF21 is a key regulator of energy balance and metabolism in mammals, and has emerged as a therapeutic potential for treating obesity and diabetes. Here, we report that mRNAs encoding FGF21 and its receptors are widely distributed within the zebrafish tissues and are importantly modulated by fasting (decreased in brain and liver, and increased in gut). FGF21 stimulates food intake in zebrafish, likely in part by modulating brain npy/agrp and nucb2/nesfatin-1 and gut ghrelin and cck mRNA expression. In accordance with this orexigenic role, the expression of FGF21 and its receptors were observed to increase preprandially and decrease post-feeding in the foregut and/or liver. Finally, we found important evidence in favor of a role for FGF21 in regulating glucose and lipid metabolism in the zebrafish liver in a way that mimics a fasting metabolic state. Nature Publishing Group UK 2020-04-24 /pmc/articles/PMC7181725/ /pubmed/32332781 http://dx.doi.org/10.1038/s41598-020-63726-w Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Blanco, Ayelén Melisa
Bertucci, Juan Ignacio
Unniappan, Suraj
FGF21 Mimics a Fasting-Induced Metabolic State and Increases Appetite in Zebrafish
title FGF21 Mimics a Fasting-Induced Metabolic State and Increases Appetite in Zebrafish
title_full FGF21 Mimics a Fasting-Induced Metabolic State and Increases Appetite in Zebrafish
title_fullStr FGF21 Mimics a Fasting-Induced Metabolic State and Increases Appetite in Zebrafish
title_full_unstemmed FGF21 Mimics a Fasting-Induced Metabolic State and Increases Appetite in Zebrafish
title_short FGF21 Mimics a Fasting-Induced Metabolic State and Increases Appetite in Zebrafish
title_sort fgf21 mimics a fasting-induced metabolic state and increases appetite in zebrafish
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181725/
https://www.ncbi.nlm.nih.gov/pubmed/32332781
http://dx.doi.org/10.1038/s41598-020-63726-w
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