RNA methyltransferase NSUN2 promotes gastric cancer cell proliferation by repressing p57(Kip2) by an m(5)C-dependent manner

The RNA methyltransferase NSUN2 has been involved in the cell proliferation and senescence, and is upregulated in various types of cancers. However, the role and potential mechanism of NSUN2 in gastric cancer remains to be determined. Our study showed that NSUN2 was significantly upregulated in gast...

Descripción completa

Detalles Bibliográficos
Autores principales: Mei, Lin, Shen, Cheng, Miao, Ran, Wang, Jing-Zi, Cao, Mend-Da, Zhang, Yi-Sheng, Shi, Liang-Hui, Zhao, Guo-Hai, Wang, Ming-Hai, Wu, Li-Sheng, Wei, Ji-Fu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181747/
https://www.ncbi.nlm.nih.gov/pubmed/32332707
http://dx.doi.org/10.1038/s41419-020-2487-z
Descripción
Sumario:The RNA methyltransferase NSUN2 has been involved in the cell proliferation and senescence, and is upregulated in various types of cancers. However, the role and potential mechanism of NSUN2 in gastric cancer remains to be determined. Our study showed that NSUN2 was significantly upregulated in gastric cancers, compared to adjacent normal gastric tissues. Moreover, NSUN2 could promote gastric cancer cell proliferation both in vitro and in vivo. Further study demonstrated that CDKN1C (p57(Kip2)) was the potential downstream gene of regulated by NSUN2 in gastric cancer. NSUN2 could promote gastric cancer cell proliferation through repressing p57(Kip2) in an m(5)C-dependent manner. Our findings suggested that NSUN2 acted as an oncogene through promoting gastric cancer development by repressing p57(Kip2) in an m(5)C-dependent manner, which may provide a novel therapeutic target against gastric cancer.

Ejemplares similares