Cargando…

Protective role of renal proximal tubular alpha-synuclein in the pathogenesis of kidney fibrosis

Kidney fibrosis is a highly deleterious process and a final manifestation of chronic kidney disease. Alpha-(α)-synuclein (SNCA) is an actin-binding neuronal protein with various functions within the brain; however, its role in other tissues is unknown. Here, we describe the expression of SNCA in ren...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bozic, Milica, Caus, Maite, Rodrigues-Diez, Raul R., Pedraza, Neus, Ruiz-Ortega, Marta, Garí, Eloi, Gallel, Pilar, Panadés, Maria José, Martinez, Ana, Fernández, Elvira, Valdivielso, José Manuel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181766/ https://www.ncbi.nlm.nih.gov/pubmed/32327648 http://dx.doi.org/10.1038/s41467-020-15732-9

Ejemplares similares

Glutamate-Gated NMDA Receptors: Insights into the Function and Signaling in the Kidney
por: Valdivielso, José M., et al.
Publicado: (2020)

Role of microRNAs in Obesity-Related Kidney Disease
por: Caus, Maite, et al.
Publicado: (2021)

Effects of the Administration of 25(OH) Vitamin D3 in an Experimental Model of Chronic Kidney Disease in Animals Null for 1-Alpha-Hydroxylase
por: Torremadé, Noelia, et al.
Publicado: (2017)

Machine learning analysis of serum biomarkers for cardiovascular risk assessment in chronic kidney disease
por: Forné, Carles, et al.
Publicado: (2019)

Association of a single nucleotide polymorphism combination pattern of the Klotho gene with non-cardiovascular death in patients with chronic kidney disease
por: Cambray, Serafi, et al.
Publicado: (2020)

Extracellular Vesicles and Renal Fibrosis: An Odyssey toward a New Therapeutic Approach
por: Kosanović, Maja, et al.
Publicado: (2021)

Magnesium Levels Modify the Effect of Lipid Parameters on Carotid Intima Media Thickness
por: Cambray, Serafi, et al.
Publicado: (2020)

Proximal Tubular Hypertrophy and Enlarged Glomerular and Proximal Tubular Urinary Space in Obese Subjects with Proteinuria
por: Tobar, Ana, et al.
Publicado: (2013)

Pathogenesis of infectious bronchitis nephritis 1. Morphometric analysis of kidney proximal tubular epithelium in chickens
por: Condron, R.J., et al.
Publicado: (1986)

Paricalcitol Inhibits Aldosterone-Induced Proinflammatory Factors by Modulating Epidermal Growth Factor Receptor Pathway in Cultured Tubular Epithelial Cells
por: Morgado-Pascual, Jose L., et al.
Publicado: (2015)

Association of Candidate Gene Polymorphisms With Chronic Kidney Disease: Results of a Case-Control Analysis in the Nefrona Cohort
por: Valls, Joan, et al.
Publicado: (2019)

The rs1126616 Single Nucleotide Polymorphism of the Osteopontin Gene Is Independently Associated with Cardiovascular Events in a Chronic Kidney Disease Cohort
por: Cambray, Serafí, et al.
Publicado: (2019)

Impaired Vitamin D Signaling in Endothelial Cell Leads to an Enhanced Leukocyte-Endothelium Interplay: Implications for Atherosclerosis Development
por: Bozic, Milica, et al.
Publicado: (2015)

Peritoneal Dialysis Is an Independent Factor Associated to Lower Intima Media Thickness in Dialysis Patients Free From Previous Cardiovascular Disease
por: Borràs, Mercè, et al.
Publicado: (2018)

Antitumor Effects of Ral-GTPases Downregulation in Glioblastoma
por: Cemeli, Tània, et al.
Publicado: (2022)

Metabolic mechanisms of acute proximal tubular injury
por: Hall, Andrew M., et al.
Publicado: (2022)

CCN2 Binds to Tubular Epithelial Cells in the Kidney
por: Rayego-Mateos, Sandra, et al.
Publicado: (2022)

Loss of tubular creatinine secretion as the only sign of tubular proximal cell dysfunction in light chain proximal tubulopathy: A case report
por: Stehlé, Thomas, et al.
Publicado: (2016)

Proximal Tubular Cell–Specific Ablation of Carnitine Acetyltransferase Causes Tubular Disease and Secondary Glomerulosclerosis
por: Kruger, Claudia, et al.
Publicado: (2019)

Motile Cilia on Kidney Proximal Tubular Epithelial Cells Are Associated With Tubular Injury and Interstitial Fibrosis
por: Eymael, Jennifer, et al.
Publicado: (2022)

Sodium and Water Transport in Kidney Proximal Tubular Cells
por: Whittembury, Guillermo
Publicado: (1968)

Ex vivo analysis of renal proximal tubular cells
por: Legouis, David, et al.
Publicado: (2015)

Proximal renal tubular acidosis with and without Fanconi syndrome
por: Kashoor, Ibrahim, et al.
Publicado: (2019)

Assessment of kidney proximal tubular secretion in critical illness
por: Bhatraju, Pavan K., et al.
Publicado: (2021)

Emerging roles of proximal tubular endocytosis in renal fibrosis
por: Chen, Min, et al.
Publicado: (2023)

Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin
por: Fusté, Noel P., et al.
Publicado: (2016)

Role of Epidermal Growth Factor Receptor (EGFR) and Its Ligands in Kidney Inflammation and Damage
por: Rayego-Mateos, Sandra, et al.
Publicado: (2018)

Detailed investigations of proximal tubular function in Imerslund-Gräsbeck syndrome
por: Storm, Tina, et al.
Publicado: (2013)

Proximal Tubular Expression Patterns of Megalin and Cubilin in Proteinuric Nephropathies
por: Sun, Jia, et al.
Publicado: (2017)

Effects of Nitric Oxide on Renal Proximal Tubular Na(+) Transport
por: Satoh, Nobuhiko, et al.
Publicado: (2017)

Mitochondrial Dynamics of Proximal Tubular Epithelial Cells in Nephropathic Cystinosis
por: De Rasmo, Domenico, et al.
Publicado: (2019)

Expression of immunoglobulin G in human proximal tubular epithelial cells
por: Deng, Zhenling, et al.
Publicado: (2021)

Direct evidence of proximal tubular proliferation in early diabetic nephropathy
por: Uehara-Watanabe, Noriko, et al.
Publicado: (2022)

Cyclin D1—Cdk4 regulates neuronal activity through phosphorylation of GABAA receptors
por: Pedraza, Neus, et al.
Publicado: (2023)

Serum Phosphate Levels Modify the Impact of FGF23 Levels on Hemoglobin in Chronic Kidney Disease
por: Navarro-González, Juan F., et al.
Publicado: (2022)

Editorial: Biomarkers and Pathogenesis of Alpha-Synuclein in Parkinson's Disease
por: Li, Puyu, et al.
Publicado: (2021)

Both Specific Endothelial and Proximal Tubular Adam17 Deletion Protect against Diabetic Nephropathy
por: Palau, Vanesa, et al.
Publicado: (2021)

Deferasirox-induced iron depletion promotes BclxL downregulation and death of proximal tubular cells
por: Martin-Sanchez, Diego, et al.
Publicado: (2017)

Molecular Mechanisms of Receptor-Mediated Endocytosis in the Renal Proximal Tubular Epithelium
por: Saito, Akihiko, et al.
Publicado: (2010)

Ischemic postconditioning inhibits apoptosis in an in vitro proximal tubular cell model
por: WENG, XIAODONG, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_2dknrqlfh6c425vnjo9lo8657b