Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic surveillance systems and modulates IL-1β production

Genetic diversity of Mycobacterium tuberculosis affects immune responses and clinical outcomes of tuberculosis (TB). However, how bacterial diversity orchestrates immune responses to direct distinct TB severities is unknown. Here we study 681 patients with pulmonary TB and show that M. tuberculosis...

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Detalles Bibliográficos
Autores principales: Sousa, Jeremy, Cá, Baltazar, Maceiras, Ana Raquel, Simões-Costa, Luisa, Fonseca, Kaori L., Fernandes, Ana Isabel, Ramos, Angélica, Carvalho, Teresa, Barros, Leandro, Magalhães, Carlos, Chiner-Oms, Álvaro, Machado, Henrique, Veiga, Maria Isabel, Singh, Albel, Pereira, Rui, Amorim, António, Vieira, Jorge, Vieira, Cristina P., Bhatt, Apoorva, Rodrigues, Fernando, Rodrigues, Pedro N. S., Gagneux, Sebastien, Castro, António Gil, Guimarães, João Tiago, Bastos, Helder Novais, Osório, Nuno S., Comas, Iñaki, Saraiva, Margarida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181847/
https://www.ncbi.nlm.nih.gov/pubmed/32327653
http://dx.doi.org/10.1038/s41467-020-15832-6

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