Serologic Detection of Middle East Respiratory Syndrome Coronavirus Functional Antibodies

We developed and validated 2 species-independent protein-based assays to detect Middle East respiratory syndrome coronavirus functional antibodies that can block virus receptor-binding or sialic acid-attachment. Antibody levels measured in both assays correlated strongly with virus-neutralizing anti...

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Detalles Bibliográficos
Autores principales: Okba, Nisreen M.A., Widjaja, Ivy, Li, Wentao, GeurtsvanKessel, Corine H., Farag, Elmoubasher A.B.A., Al-Hajri, Mohammed, Park, Wan Beom, Oh, Myoung-don, Reusken, Chantal B.E.M., Koopmans, Marion P.G., Bosch, Berend-Jan, Haagmans, Bart L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2020
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181916/
https://www.ncbi.nlm.nih.gov/pubmed/32150528
http://dx.doi.org/10.3201/eid2605.190921
Descripción
Sumario:We developed and validated 2 species-independent protein-based assays to detect Middle East respiratory syndrome coronavirus functional antibodies that can block virus receptor-binding or sialic acid-attachment. Antibody levels measured in both assays correlated strongly with virus-neutralizing antibody titers, proving their use for serologic confirmatory diagnosis of Middle East respiratory syndrome.

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