Cargando…

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

We have previously provided the first genetic evidence that angiotensin converting enzyme 2 (ACE2) is the critical receptor for severe acute respiratory syndrome coronavirus (SARS-CoV), and ACE2 protects the lung from injury, providing a molecular explanation for the severe lung failure and death du...

Descripción completa

Detalles Bibliográficos
Autores principales:	Monteil, Vanessa, Kwon, Hyesoo, Prado, Patricia, Hagelkrüys, Astrid, Wimmer, Reiner A., Stahl, Martin, Leopoldi, Alexandra, Garreta, Elena, Hurtado del Pozo, Carmen, Prosper, Felipe, Romero, Juan Pablo, Wirnsberger, Gerald, Zhang, Haibo, Slutsky, Arthur S., Conder, Ryan, Montserrat, Nuria, Mirazimi, Ali, Penninger, Josef M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Inc. 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181998/ https://www.ncbi.nlm.nih.gov/pubmed/32333836 http://dx.doi.org/10.1016/j.cell.2020.04.004

Ejemplares similares

Human soluble ACE2 improves the effect of remdesivir in SARS‐CoV‐2 infection
por: Monteil, Vanessa, et al.
Publicado: (2020)

A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells
por: Garreta, Elena, et al.
Publicado: (2022)

Evidence in favor of the essentiality of human cell membrane-bound ACE2 and against soluble ACE2 for SARS-CoV-2 infectivity
por: Batlle, Daniel, et al.
Publicado: (2022)

Protocol for SARS-CoV-2 infection of kidney organoids derived from human pluripotent stem cells
por: Garreta, Elena, et al.
Publicado: (2022)

Human recombinant soluble ACE2 in severe COVID-19
por: Zoufaly, Alexander, et al.
Publicado: (2020)

Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants
por: Wirnsberger, Gerald, et al.
Publicado: (2021)

ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology
por: Gawish, Riem, et al.
Publicado: (2022)

Identification of CCZ1 as an essential lysosomal trafficking regulator in Marburg and Ebola virus infections
por: Monteil, Vanessa, et al.
Publicado: (2023)

Clinical grade ACE2 as a universal agent to block SARS‐CoV‐2 variants
por: Monteil, Vanessa, et al.
Publicado: (2022)

Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target
por: Zhang, Haibo, et al.
Publicado: (2020)

Redirecting Imipramine against Bluetongue Virus Infection: Insights from a Genome-wide Haploid Screening Study
por: John, Lijo, et al.
Publicado: (2022)

Structure-guided glyco-engineering of ACE2 for improved potency as soluble SARS-CoV-2 decoy receptor
por: Capraz, Tümay, et al.
Publicado: (2021)

Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level
por: Zhu, Rong, et al.
Publicado: (2022)

Modeling epigenetic modifications in renal development and disease with organoids and genome editing
por: Hurtado del Pozo, Carmen, et al.
Publicado: (2018)

Low-density lipoprotein receptor–related protein 1 (LRP1) as an auxiliary host factor for RNA viruses
por: Devignot, Stephanie, et al.
Publicado: (2023)

Author Correction: Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level
por: Zhu, Rong, et al.
Publicado: (2023)

A crucial role for Jagunal homolog 1 in humoral immunity and antibody glycosylation in mice and humans
por: Hagelkruys, Astrid, et al.
Publicado: (2020)

Recombinant human ACE2: acing out angiotensin II in ARDS therapy
por: Zhang, Haibo, et al.
Publicado: (2017)

Generation of enzymatically competent SARS‐CoV‐2 decoy receptor ACE2‐Fc in glycoengineered Nicotiana benthamiana
por: Castilho, Alexandra, et al.
Publicado: (2021)

Non-coding microRNAs for cardiac regeneration: Exploring novel alternatives to induce heart healing
por: Garreta, Elena, et al.
Publicado: (2017)

Identification of lectin receptors for conserved SARS‐CoV‐2 glycosylation sites
por: Hoffmann, David, et al.
Publicado: (2021)

Inhalation of ACE2 as a therapeutic target on sex-bias differences in SARS-CoV-2 infection and variant of concern
por: Onodera, Yu, et al.
Publicado: (2023)

Assessing kidney development and disease using kidney organoids and CRISPR engineering
por: Safi, Wajima, et al.
Publicado: (2022)

Human Recombinant ACE2 Reduces the Progression of Diabetic Nephropathy
por: Oudit, Gavin Y., et al.
Publicado: (2010)

Genome-wide spatial expression profiling in formalin-fixed tissues
por: Gracia Villacampa, Eva, et al.
Publicado: (2021)

ACE2 – From the renin–angiotensin system to gut microbiota and malnutrition
por: Perlot, Thomas, et al.
Publicado: (2013)

Further comments on the role of ACE‐2 positive macrophages in human lung
por: Hu, Wei, et al.
Publicado: (2021)

Neuropeptide Neuromedin B does not alter body weight and glucose homeostasis nor does it act as an insulin-releasing peptide
por: Cikes, Domagoj, et al.
Publicado: (2022)

Kidney organoids for disease modeling
por: Garreta, Elena, et al.
Publicado: (2018)

Angiotensin-Converting Enzyme 2 (ACE2) in the Pathogenesis of ARDS in COVID-19
por: Kuba, Keiji, et al.
Publicado: (2021)

ACE phenotyping in human heart
por: Tikhomirova, Victoria E., et al.
Publicado: (2017)

A single allele of Hdac2 but not Hdac1 is sufficient for normal mouse brain development in the absence of its paralog
por: Hagelkruys, Astrid, et al.
Publicado: (2014)

ACE inhibitors on ACE1, ACE2, and TMPRSS2 expression and spheroid attachment on human endometrial Ishikawa cells
por: Fernando, Sudini R., et al.
Publicado: (2022)

Lessons from SARS: control of acute lung failure by the SARS receptor ACE2
por: Kuba, Keiji, et al.
Publicado: (2006)

ACE2 Receptor and Its Isoform Short-ACE2 Are Expressed on Human Spermatozoa
por: Ramal-Sanchez, Marina, et al.
Publicado: (2022)

Transcription and beyond: the role of mammalian class I lysine deacetylases
por: Moser, Mirjam Andrea, et al.
Publicado: (2013)

Roadblocks in the Path of iPSC to the Clinic
por: Garreta, Elena, et al.
Publicado: (2018)

Contact-dependent signaling triggers tumor-like proliferation of CCM3 knockout endothelial cells in co-culture with wild-type cells
por: Rath, Matthias, et al.
Publicado: (2022)

A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury
por: Kuba, Keiji, et al.
Publicado: (2005)

Effect of age on human ACE2 and ACE2-expressing alveolar type II cells levels
por: Silva, Mauro G., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_8u4o726v7ihkqv74ggg60v67gn