Adverse drug events and the associated factors in patients with chronic Chagas disease

INTRODUCTION: Herein, we aimed to identify the factors associated with adverse drug events (ADEs) in chronic Chagas disease (CD) patients. METHODS: We analyzed 320 medical notes from 295 patients. The Naranjo algorithm was applied to determine the cause of ADEs. Mixed effects logistic regression was...

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Detalles Bibliográficos
Autores principales: Lopes, Luiza Braz da Cunha, Pereira, Raquel Rodrigues, Andrade, Patricia Mello, Carneiro, Fernanda Martins, Mediano, Mauro Felippe Felix, Kilgore, Sophia Isabel Linnemann, Hasslocher-Moreno, Alejandro Marcel, de Sousa, Andréa Silvestre, Oliveira, Manoel Marques Evangelista, Saraiva, Roberto Magalhães, de Holanda, Marcelo Teixeira, da Silva, Gilberto Marcelo Sperandio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Medicina Tropical - SBMT 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182287/
https://www.ncbi.nlm.nih.gov/pubmed/32321092
http://dx.doi.org/10.1590/0037-8682-0443-2019
Descripción
Sumario:INTRODUCTION: Herein, we aimed to identify the factors associated with adverse drug events (ADEs) in chronic Chagas disease (CD) patients. METHODS: We analyzed 320 medical notes from 295 patients. The Naranjo algorithm was applied to determine the cause of ADEs. Mixed effects logistic regression was performed to evaluate the factors associated with ADEs. RESULTS: ADEs were described in 102 medical notes (31.9%). Captopril was most frequently associated with ADEs. Age (RR 0.96; 95%CI 0.94-0.99) and cardiac C/D stages (RR 3.24; 95%CI 1.30-4.58) were the most important clinical factors associated with ADEs. CONCLUSIONS: Close follow-up is warranted for CD patients.

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