Adverse drug events and the associated factors in patients with chronic Chagas disease

INTRODUCTION: Herein, we aimed to identify the factors associated with adverse drug events (ADEs) in chronic Chagas disease (CD) patients. METHODS: We analyzed 320 medical notes from 295 patients. The Naranjo algorithm was applied to determine the cause of ADEs. Mixed effects logistic regression was...

Descripción completa

Detalles Bibliográficos
Autores principales: Lopes, Luiza Braz da Cunha, Pereira, Raquel Rodrigues, Andrade, Patricia Mello, Carneiro, Fernanda Martins, Mediano, Mauro Felippe Felix, Kilgore, Sophia Isabel Linnemann, Hasslocher-Moreno, Alejandro Marcel, de Sousa, Andréa Silvestre, Oliveira, Manoel Marques Evangelista, Saraiva, Roberto Magalhães, de Holanda, Marcelo Teixeira, da Silva, Gilberto Marcelo Sperandio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Medicina Tropical - SBMT 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182287/
https://www.ncbi.nlm.nih.gov/pubmed/32321092
http://dx.doi.org/10.1590/0037-8682-0443-2019
_version_ 1783526217063858176
author Lopes, Luiza Braz da Cunha
Pereira, Raquel Rodrigues
Andrade, Patricia Mello
Carneiro, Fernanda Martins
Mediano, Mauro Felippe Felix
Kilgore, Sophia Isabel Linnemann
Hasslocher-Moreno, Alejandro Marcel
de Sousa, Andréa Silvestre
Oliveira, Manoel Marques Evangelista
Saraiva, Roberto Magalhães
de Holanda, Marcelo Teixeira
da Silva, Gilberto Marcelo Sperandio
author_facet Lopes, Luiza Braz da Cunha
Pereira, Raquel Rodrigues
Andrade, Patricia Mello
Carneiro, Fernanda Martins
Mediano, Mauro Felippe Felix
Kilgore, Sophia Isabel Linnemann
Hasslocher-Moreno, Alejandro Marcel
de Sousa, Andréa Silvestre
Oliveira, Manoel Marques Evangelista
Saraiva, Roberto Magalhães
de Holanda, Marcelo Teixeira
da Silva, Gilberto Marcelo Sperandio
author_sort Lopes, Luiza Braz da Cunha
collection PubMed
description INTRODUCTION: Herein, we aimed to identify the factors associated with adverse drug events (ADEs) in chronic Chagas disease (CD) patients. METHODS: We analyzed 320 medical notes from 295 patients. The Naranjo algorithm was applied to determine the cause of ADEs. Mixed effects logistic regression was performed to evaluate the factors associated with ADEs. RESULTS: ADEs were described in 102 medical notes (31.9%). Captopril was most frequently associated with ADEs. Age (RR 0.96; 95%CI 0.94-0.99) and cardiac C/D stages (RR 3.24; 95%CI 1.30-4.58) were the most important clinical factors associated with ADEs. CONCLUSIONS: Close follow-up is warranted for CD patients.
format Online
Article
Text
id pubmed-7182287
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Sociedade Brasileira de Medicina Tropical - SBMT
record_format MEDLINE/PubMed
spelling pubmed-71822872020-04-27 Adverse drug events and the associated factors in patients with chronic Chagas disease Lopes, Luiza Braz da Cunha Pereira, Raquel Rodrigues Andrade, Patricia Mello Carneiro, Fernanda Martins Mediano, Mauro Felippe Felix Kilgore, Sophia Isabel Linnemann Hasslocher-Moreno, Alejandro Marcel de Sousa, Andréa Silvestre Oliveira, Manoel Marques Evangelista Saraiva, Roberto Magalhães de Holanda, Marcelo Teixeira da Silva, Gilberto Marcelo Sperandio Rev Soc Bras Med Trop Short Communication INTRODUCTION: Herein, we aimed to identify the factors associated with adverse drug events (ADEs) in chronic Chagas disease (CD) patients. METHODS: We analyzed 320 medical notes from 295 patients. The Naranjo algorithm was applied to determine the cause of ADEs. Mixed effects logistic regression was performed to evaluate the factors associated with ADEs. RESULTS: ADEs were described in 102 medical notes (31.9%). Captopril was most frequently associated with ADEs. Age (RR 0.96; 95%CI 0.94-0.99) and cardiac C/D stages (RR 3.24; 95%CI 1.30-4.58) were the most important clinical factors associated with ADEs. CONCLUSIONS: Close follow-up is warranted for CD patients. Sociedade Brasileira de Medicina Tropical - SBMT 2020-04-22 /pmc/articles/PMC7182287/ /pubmed/32321092 http://dx.doi.org/10.1590/0037-8682-0443-2019 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Short Communication
Lopes, Luiza Braz da Cunha
Pereira, Raquel Rodrigues
Andrade, Patricia Mello
Carneiro, Fernanda Martins
Mediano, Mauro Felippe Felix
Kilgore, Sophia Isabel Linnemann
Hasslocher-Moreno, Alejandro Marcel
de Sousa, Andréa Silvestre
Oliveira, Manoel Marques Evangelista
Saraiva, Roberto Magalhães
de Holanda, Marcelo Teixeira
da Silva, Gilberto Marcelo Sperandio
Adverse drug events and the associated factors in patients with chronic Chagas disease
title Adverse drug events and the associated factors in patients with chronic Chagas disease
title_full Adverse drug events and the associated factors in patients with chronic Chagas disease
title_fullStr Adverse drug events and the associated factors in patients with chronic Chagas disease
title_full_unstemmed Adverse drug events and the associated factors in patients with chronic Chagas disease
title_short Adverse drug events and the associated factors in patients with chronic Chagas disease
title_sort adverse drug events and the associated factors in patients with chronic chagas disease
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182287/
https://www.ncbi.nlm.nih.gov/pubmed/32321092
http://dx.doi.org/10.1590/0037-8682-0443-2019
work_keys_str_mv AT lopesluizabrazdacunha adversedrugeventsandtheassociatedfactorsinpatientswithchronicchagasdisease
AT pereiraraquelrodrigues adversedrugeventsandtheassociatedfactorsinpatientswithchronicchagasdisease
AT andradepatriciamello adversedrugeventsandtheassociatedfactorsinpatientswithchronicchagasdisease
AT carneirofernandamartins adversedrugeventsandtheassociatedfactorsinpatientswithchronicchagasdisease
AT medianomaurofelippefelix adversedrugeventsandtheassociatedfactorsinpatientswithchronicchagasdisease
AT kilgoresophiaisabellinnemann adversedrugeventsandtheassociatedfactorsinpatientswithchronicchagasdisease
AT hasslochermorenoalejandromarcel adversedrugeventsandtheassociatedfactorsinpatientswithchronicchagasdisease
AT desousaandreasilvestre adversedrugeventsandtheassociatedfactorsinpatientswithchronicchagasdisease
AT oliveiramanoelmarquesevangelista adversedrugeventsandtheassociatedfactorsinpatientswithchronicchagasdisease
AT saraivarobertomagalhaes adversedrugeventsandtheassociatedfactorsinpatientswithchronicchagasdisease
AT deholandamarceloteixeira adversedrugeventsandtheassociatedfactorsinpatientswithchronicchagasdisease
AT dasilvagilbertomarcelosperandio adversedrugeventsandtheassociatedfactorsinpatientswithchronicchagasdisease

Ejemplares similares