A tunable orthogonal coiled-coil interaction toolbox for engineering mammalian cells

Protein interactions guide the majority of cellular processes. Orthogonal hetero-specific protein-protein interaction domains may facilitate better control of engineered biological systems. Here, we report a tunable de novo designed set of orthogonal coiled-coil (CC) peptide heterodimers (the NICP s...

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Detalles Bibliográficos
Autores principales: Lebar, Tina, Lainšček, Duško, Merljak, Estera, Aupič, Jana, Jerala, Roman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182445/
https://www.ncbi.nlm.nih.gov/pubmed/31907374
http://dx.doi.org/10.1038/s41589-019-0443-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182445/
https://www.ncbi.nlm.nih.gov/pubmed/31907374
http://dx.doi.org/10.1038/s41589-019-0443-y

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