Carryover effects of baloxavir acid in human nasopharyngeal/pharyngeal swabs on infectious titer testing of influenza virus

Baloxavir marboxil (BXM) demonstrated a rapid and profound decline in infectious viral titer 1 day after BXM administration. Rapid reduction in virus titer is a characteristic of BXM. There may be a possibility that drug carryover effects have impacts on the observed antiviral effects due to the poo...

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Autores principales: Baba, Keiko, Oka, Ryoko, Shano, Shinya, Omoto, Shinya, Noshi, Takeshi, Shishido, Takao, Naito, Akira, Kawaguchi, Keiko, Ishibashi, Toru, Uehara, Takeki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Short Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182602/
https://www.ncbi.nlm.nih.gov/pubmed/31994309
http://dx.doi.org/10.1111/irv.12721
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author Baba, Keiko
Oka, Ryoko
Shano, Shinya
Omoto, Shinya
Noshi, Takeshi
Shishido, Takao
Naito, Akira
Kawaguchi, Keiko
Ishibashi, Toru
Uehara, Takeki
author_facet Baba, Keiko
Oka, Ryoko
Shano, Shinya
Omoto, Shinya
Noshi, Takeshi
Shishido, Takao
Naito, Akira
Kawaguchi, Keiko
Ishibashi, Toru
Uehara, Takeki
author_sort Baba, Keiko
collection PubMed
description Baloxavir marboxil (BXM) demonstrated a rapid and profound decline in infectious viral titer 1 day after BXM administration. Rapid reduction in virus titer is a characteristic of BXM. There may be a possibility that drug carryover effects have impacts on the observed antiviral effects due to the poor correlation that was observed between viral titer reduction and alleviation of influenza symptoms. Here, we report possible carryover effects of baloxavir acid (BXA), an active form of BXM, on infectious titer testing. Our findings indicate that there is little impact of BXA carryover on the infectious titer testing.
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spelling pubmed-71826022020-05-01 Carryover effects of baloxavir acid in human nasopharyngeal/pharyngeal swabs on infectious titer testing of influenza virus Baba, Keiko Oka, Ryoko Shano, Shinya Omoto, Shinya Noshi, Takeshi Shishido, Takao Naito, Akira Kawaguchi, Keiko Ishibashi, Toru Uehara, Takeki Influenza Other Respir Viruses Short Articles Baloxavir marboxil (BXM) demonstrated a rapid and profound decline in infectious viral titer 1 day after BXM administration. Rapid reduction in virus titer is a characteristic of BXM. There may be a possibility that drug carryover effects have impacts on the observed antiviral effects due to the poor correlation that was observed between viral titer reduction and alleviation of influenza symptoms. Here, we report possible carryover effects of baloxavir acid (BXA), an active form of BXM, on infectious titer testing. Our findings indicate that there is little impact of BXA carryover on the infectious titer testing. John Wiley and Sons Inc. 2020-01-28 2020-05 /pmc/articles/PMC7182602/ /pubmed/31994309 http://dx.doi.org/10.1111/irv.12721 Text en © 2020 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Articles
Baba, Keiko
Oka, Ryoko
Shano, Shinya
Omoto, Shinya
Noshi, Takeshi
Shishido, Takao
Naito, Akira
Kawaguchi, Keiko
Ishibashi, Toru
Uehara, Takeki
Carryover effects of baloxavir acid in human nasopharyngeal/pharyngeal swabs on infectious titer testing of influenza virus
title Carryover effects of baloxavir acid in human nasopharyngeal/pharyngeal swabs on infectious titer testing of influenza virus
title_full Carryover effects of baloxavir acid in human nasopharyngeal/pharyngeal swabs on infectious titer testing of influenza virus
title_fullStr Carryover effects of baloxavir acid in human nasopharyngeal/pharyngeal swabs on infectious titer testing of influenza virus
title_full_unstemmed Carryover effects of baloxavir acid in human nasopharyngeal/pharyngeal swabs on infectious titer testing of influenza virus
title_short Carryover effects of baloxavir acid in human nasopharyngeal/pharyngeal swabs on infectious titer testing of influenza virus
title_sort carryover effects of baloxavir acid in human nasopharyngeal/pharyngeal swabs on infectious titer testing of influenza virus
topic Short Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182602/
https://www.ncbi.nlm.nih.gov/pubmed/31994309
http://dx.doi.org/10.1111/irv.12721
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