Severe metabolic alterations in liver cancer lead to ERK pathway activation and drug resistance

BACKGROUND: The extracellular signal-regulated kinase (ERK) pathway regulates cell growth, and is hyper-activated and associated with drug resistance in hepatocellular carcinoma (HCC). Metabolic pathways are profoundly dysregulated in HCC. Whether an altered metabolic state is linked to activated ER...

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Detalles Bibliográficos
Autores principales: Nwosu, Zeribe Chike, Piorońska, Weronika, Battello, Nadia, Zimmer, Andreas David, Dewidar, Bedair, Han, Mei, Pereira, Sharon, Blagojevic, Biljana, Castven, Darko, Charlestin, Verodia, Holenya, Pavlo, Lochead, Julia, De La Torre, Carolina, Gretz, Norbert, Sajjakulnukit, Peter, Zhang, Li, Ward, Matthew H., Marquardt, Jens U., di Magliano, Marina Pasca, Lyssiotis, Costas A., Sleeman, Jonathan, Wölfl, Stefan, Ebert, Matthias Philip, Meyer, Christoph, Hofmann, Ute, Dooley, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182727/
https://www.ncbi.nlm.nih.gov/pubmed/32330875
http://dx.doi.org/10.1016/j.ebiom.2020.102699

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