In vitro testing of combined hydroxychloroquine and azithromycin on SARS-CoV-2 shows synergistic effect

Human coronaviruses SARS-CoV-2 appeared at the end of 2019 and led to a pandemic with high morbidity and mortality. As there are currently no effective drugs targeting this virus, drug repurposing represents a short-term strategy to treat millions of infected patients at low costs. Hydroxychloroquin...

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Autores principales: Andreani, Julien, Le Bideau, Marion, Duflot, Isabelle, Jardot, Priscilla, Rolland, Clara, Boxberger, Manon, Wurtz, Nathalie, Rolain, Jean-Marc, Colson, Philippe, La Scola, Bernard, Raoult, Didier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 2020
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182748/
https://www.ncbi.nlm.nih.gov/pubmed/32344177
http://dx.doi.org/10.1016/j.micpath.2020.104228
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author Andreani, Julien
Le Bideau, Marion
Duflot, Isabelle
Jardot, Priscilla
Rolland, Clara
Boxberger, Manon
Wurtz, Nathalie
Rolain, Jean-Marc
Colson, Philippe
La Scola, Bernard
Raoult, Didier
author_facet Andreani, Julien
Le Bideau, Marion
Duflot, Isabelle
Jardot, Priscilla
Rolland, Clara
Boxberger, Manon
Wurtz, Nathalie
Rolain, Jean-Marc
Colson, Philippe
La Scola, Bernard
Raoult, Didier
author_sort Andreani, Julien
collection PubMed
description Human coronaviruses SARS-CoV-2 appeared at the end of 2019 and led to a pandemic with high morbidity and mortality. As there are currently no effective drugs targeting this virus, drug repurposing represents a short-term strategy to treat millions of infected patients at low costs. Hydroxychloroquine showed an antiviral effect in vitro. In vivo it showed efficacy, especially when combined with azithromycin in a preliminary clinical trial. Here we demonstrate that the combination of hydroxychloroquine and azithromycin has a synergistic effect in vitro on SARS-CoV-2 at concentrations compatible with that obtained in human lung.
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spelling pubmed-71827482020-04-27 In vitro testing of combined hydroxychloroquine and azithromycin on SARS-CoV-2 shows synergistic effect Andreani, Julien Le Bideau, Marion Duflot, Isabelle Jardot, Priscilla Rolland, Clara Boxberger, Manon Wurtz, Nathalie Rolain, Jean-Marc Colson, Philippe La Scola, Bernard Raoult, Didier Microb Pathog Article Human coronaviruses SARS-CoV-2 appeared at the end of 2019 and led to a pandemic with high morbidity and mortality. As there are currently no effective drugs targeting this virus, drug repurposing represents a short-term strategy to treat millions of infected patients at low costs. Hydroxychloroquine showed an antiviral effect in vitro. In vivo it showed efficacy, especially when combined with azithromycin in a preliminary clinical trial. Here we demonstrate that the combination of hydroxychloroquine and azithromycin has a synergistic effect in vitro on SARS-CoV-2 at concentrations compatible with that obtained in human lung. Published by Elsevier Ltd. 2020-08 2020-04-25 /pmc/articles/PMC7182748/ /pubmed/32344177 http://dx.doi.org/10.1016/j.micpath.2020.104228 Text en © 2020 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Andreani, Julien
Le Bideau, Marion
Duflot, Isabelle
Jardot, Priscilla
Rolland, Clara
Boxberger, Manon
Wurtz, Nathalie
Rolain, Jean-Marc
Colson, Philippe
La Scola, Bernard
Raoult, Didier
In vitro testing of combined hydroxychloroquine and azithromycin on SARS-CoV-2 shows synergistic effect
title In vitro testing of combined hydroxychloroquine and azithromycin on SARS-CoV-2 shows synergistic effect
title_full In vitro testing of combined hydroxychloroquine and azithromycin on SARS-CoV-2 shows synergistic effect
title_fullStr In vitro testing of combined hydroxychloroquine and azithromycin on SARS-CoV-2 shows synergistic effect
title_full_unstemmed In vitro testing of combined hydroxychloroquine and azithromycin on SARS-CoV-2 shows synergistic effect
title_short In vitro testing of combined hydroxychloroquine and azithromycin on SARS-CoV-2 shows synergistic effect
title_sort in vitro testing of combined hydroxychloroquine and azithromycin on sars-cov-2 shows synergistic effect
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182748/
https://www.ncbi.nlm.nih.gov/pubmed/32344177
http://dx.doi.org/10.1016/j.micpath.2020.104228
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