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Projecting hospital utilization during the COVID-19 outbreaks in the United States

In the wake of community coronavirus disease 2019 (COVID-19) transmission in the United States, there is a growing public health concern regarding the adequacy of resources to treat infected cases. Hospital beds, intensive care units (ICUs), and ventilators are vital for the treatment of patients wi...

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Autores principales: Moghadas, Seyed M., Shoukat, Affan, Fitzpatrick, Meagan C., Wells, Chad R., Sah, Pratha, Pandey, Abhishek, Sachs, Jeffrey D., Wang, Zheng, Meyers, Lauren A., Singer, Burton H., Galvani, Alison P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183199/
https://www.ncbi.nlm.nih.gov/pubmed/32245814
http://dx.doi.org/10.1073/pnas.2004064117
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author Moghadas, Seyed M.
Shoukat, Affan
Fitzpatrick, Meagan C.
Wells, Chad R.
Sah, Pratha
Pandey, Abhishek
Sachs, Jeffrey D.
Wang, Zheng
Meyers, Lauren A.
Singer, Burton H.
Galvani, Alison P.
author_facet Moghadas, Seyed M.
Shoukat, Affan
Fitzpatrick, Meagan C.
Wells, Chad R.
Sah, Pratha
Pandey, Abhishek
Sachs, Jeffrey D.
Wang, Zheng
Meyers, Lauren A.
Singer, Burton H.
Galvani, Alison P.
author_sort Moghadas, Seyed M.
collection PubMed
description In the wake of community coronavirus disease 2019 (COVID-19) transmission in the United States, there is a growing public health concern regarding the adequacy of resources to treat infected cases. Hospital beds, intensive care units (ICUs), and ventilators are vital for the treatment of patients with severe illness. To project the timing of the outbreak peak and the number of ICU beds required at peak, we simulated a COVID-19 outbreak parameterized with the US population demographics. In scenario analyses, we varied the delay from symptom onset to self-isolation, the proportion of symptomatic individuals practicing self-isolation, and the basic reproduction number R(0). Without self-isolation, when R(0) = 2.5, treatment of critically ill individuals at the outbreak peak would require 3.8 times more ICU beds than exist in the United States. Self-isolation by 20% of cases 24 h after symptom onset would delay and flatten the outbreak trajectory, reducing the number of ICU beds needed at the peak by 48.4% (interquartile range 46.4–50.3%), although still exceeding existing capacity. When R(0) = 2, twice as many ICU beds would be required at the peak of outbreak in the absence of self-isolation. In this scenario, the proportional impact of self-isolation within 24 h on reducing the peak number of ICU beds is substantially higher at 73.5% (interquartile range 71.4–75.3%). Our estimates underscore the inadequacy of critical care capacity to handle the burgeoning outbreak. Policies that encourage self-isolation, such as paid sick leave, may delay the epidemic peak, giving a window of time that could facilitate emergency mobilization to expand hospital capacity.
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spelling pubmed-71831992020-05-01 Projecting hospital utilization during the COVID-19 outbreaks in the United States Moghadas, Seyed M. Shoukat, Affan Fitzpatrick, Meagan C. Wells, Chad R. Sah, Pratha Pandey, Abhishek Sachs, Jeffrey D. Wang, Zheng Meyers, Lauren A. Singer, Burton H. Galvani, Alison P. Proc Natl Acad Sci U S A Biological Sciences In the wake of community coronavirus disease 2019 (COVID-19) transmission in the United States, there is a growing public health concern regarding the adequacy of resources to treat infected cases. Hospital beds, intensive care units (ICUs), and ventilators are vital for the treatment of patients with severe illness. To project the timing of the outbreak peak and the number of ICU beds required at peak, we simulated a COVID-19 outbreak parameterized with the US population demographics. In scenario analyses, we varied the delay from symptom onset to self-isolation, the proportion of symptomatic individuals practicing self-isolation, and the basic reproduction number R(0). Without self-isolation, when R(0) = 2.5, treatment of critically ill individuals at the outbreak peak would require 3.8 times more ICU beds than exist in the United States. Self-isolation by 20% of cases 24 h after symptom onset would delay and flatten the outbreak trajectory, reducing the number of ICU beds needed at the peak by 48.4% (interquartile range 46.4–50.3%), although still exceeding existing capacity. When R(0) = 2, twice as many ICU beds would be required at the peak of outbreak in the absence of self-isolation. In this scenario, the proportional impact of self-isolation within 24 h on reducing the peak number of ICU beds is substantially higher at 73.5% (interquartile range 71.4–75.3%). Our estimates underscore the inadequacy of critical care capacity to handle the burgeoning outbreak. Policies that encourage self-isolation, such as paid sick leave, may delay the epidemic peak, giving a window of time that could facilitate emergency mobilization to expand hospital capacity. National Academy of Sciences 2020-04-21 2020-04-03 /pmc/articles/PMC7183199/ /pubmed/32245814 http://dx.doi.org/10.1073/pnas.2004064117 Text en Copyright © 2020 the Author(s). Published by PNAS. http://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/licenses/by/4.0/This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Biological Sciences
Moghadas, Seyed M.
Shoukat, Affan
Fitzpatrick, Meagan C.
Wells, Chad R.
Sah, Pratha
Pandey, Abhishek
Sachs, Jeffrey D.
Wang, Zheng
Meyers, Lauren A.
Singer, Burton H.
Galvani, Alison P.
Projecting hospital utilization during the COVID-19 outbreaks in the United States
title Projecting hospital utilization during the COVID-19 outbreaks in the United States
title_full Projecting hospital utilization during the COVID-19 outbreaks in the United States
title_fullStr Projecting hospital utilization during the COVID-19 outbreaks in the United States
title_full_unstemmed Projecting hospital utilization during the COVID-19 outbreaks in the United States
title_short Projecting hospital utilization during the COVID-19 outbreaks in the United States
title_sort projecting hospital utilization during the covid-19 outbreaks in the united states
topic Biological Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183199/
https://www.ncbi.nlm.nih.gov/pubmed/32245814
http://dx.doi.org/10.1073/pnas.2004064117
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