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Reconstitution of polythioamide antibiotic backbone formation reveals unusual thiotemplated assembly strategy
Closthioamide (CTA) is a rare example of a thioamide-containing nonribosomal peptide and is one of only a handful of secondary metabolites described from obligately anaerobic bacteria. Although the biosynthetic gene cluster responsible for CTA production and the thioamide synthetase that catalyzes s...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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National Academy of Sciences
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183216/ https://www.ncbi.nlm.nih.gov/pubmed/32265283 http://dx.doi.org/10.1073/pnas.1918759117 |