Beta cell-specific CD8(+) T cells maintain stem-cell memory-associated epigenetic programs during type 1 diabetes

The pool of beta cell-specific CD8(+) T-cells in type 1 diabetes (T1D) sustains an autoreactive potential despite having access to a constant source of antigen. To investigate the long-lived nature of these cells, we established a DNA methylation-based T cell “multipotency index” and found that beta...

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Detalles Bibliográficos
Autores principales: Abdelsamed, Hossam A., Zebley, Caitlin C., Nguyen, Hai, Rutishauser, Rachel L., Fan, Yiping, Ghoneim, Hazem E., Crawford, Jeremy Chase, Alfei, Francesca, Alli, Shanta, Ribeiro, Susan Pereira, Castellaw, Ashley H., McGargill, Maureen A., Jin, Hongjian, Boi, Shannon K., Speake, Cate, Serti, Elisavet, Turka, Laurence A., Busch, Michael E., Stone, Mars, Deeks, Steven G., Sekaly, Rafick-Pierre, Zehn, Dietmar, James, Eddie A., Nepom, Gerald T., Youngblood, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183435/
https://www.ncbi.nlm.nih.gov/pubmed/32231298
http://dx.doi.org/10.1038/s41590-020-0633-5

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