Ionomycin ameliorates hypophosphatasia via rescuing alkaline phosphatase deficiency-mediated L-type Ca(2+) channel internalization in mesenchymal stem cells

The loss-of-function mutations in the ALPL result in hypophosphatasia (HPP), an inborn metabolic disorder that causes skeletal mineralization defects. In adults, the main clinical features are early loss of primary or secondary teeth, osteoporosis, bone pain, chondrocalcinosis, and fractures. Howeve...

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Detalles Bibliográficos
Autores principales: Li, Bei, He, Xiaoning, Dong, Zhiwei, Xuan, Kun, Sun, Wei, Gao, Li, Liu, Shiyu, Liu, Wenjia, Hu, Chenghu, Zhao, Yimin, Shi, Songtao, Jin, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183511/
https://www.ncbi.nlm.nih.gov/pubmed/32351759
http://dx.doi.org/10.1038/s41413-020-0090-7

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