Antiepithelial-Mesenchymal Transition of Herbal Active Substance in Tumor Cells via Different Signaling

Epithelial-mesenchymal transition (EMT) is a biological process through which epithelial cells differentiate into mesenchymal cells. EMT plays an important role in embryonic development and wound healing; however, EMT also contributes to some pathological processes, such as tumor metastasis and fibr...

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Detalles Bibliográficos
Autores principales: Cui, Xiaoji, Lin, Qinlu, Huang, Ping, Liang, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183534/
https://www.ncbi.nlm.nih.gov/pubmed/32377312
http://dx.doi.org/10.1155/2020/9253745
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author Cui, Xiaoji
Lin, Qinlu
Huang, Ping
Liang, Ying
author_facet Cui, Xiaoji
Lin, Qinlu
Huang, Ping
Liang, Ying
author_sort Cui, Xiaoji
collection PubMed
description Epithelial-mesenchymal transition (EMT) is a biological process through which epithelial cells differentiate into mesenchymal cells. EMT plays an important role in embryonic development and wound healing; however, EMT also contributes to some pathological processes, such as tumor metastasis and fibrosis. EMT mechanisms, including gene mutation and transcription factor regulation, are complicated and not yet well understood. In this review, we introduce some herbal active substances that exert antitumor activity through inhibiting EMT that is induced by hypoxia, high blood glucose level, lipopolysaccharide, or other factors.
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spelling pubmed-71835342020-05-06 Antiepithelial-Mesenchymal Transition of Herbal Active Substance in Tumor Cells via Different Signaling Cui, Xiaoji Lin, Qinlu Huang, Ping Liang, Ying Oxid Med Cell Longev Review Article Epithelial-mesenchymal transition (EMT) is a biological process through which epithelial cells differentiate into mesenchymal cells. EMT plays an important role in embryonic development and wound healing; however, EMT also contributes to some pathological processes, such as tumor metastasis and fibrosis. EMT mechanisms, including gene mutation and transcription factor regulation, are complicated and not yet well understood. In this review, we introduce some herbal active substances that exert antitumor activity through inhibiting EMT that is induced by hypoxia, high blood glucose level, lipopolysaccharide, or other factors. Hindawi 2020-04-17 /pmc/articles/PMC7183534/ /pubmed/32377312 http://dx.doi.org/10.1155/2020/9253745 Text en Copyright © 2020 Xiaoji Cui et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Cui, Xiaoji
Lin, Qinlu
Huang, Ping
Liang, Ying
Antiepithelial-Mesenchymal Transition of Herbal Active Substance in Tumor Cells via Different Signaling
title Antiepithelial-Mesenchymal Transition of Herbal Active Substance in Tumor Cells via Different Signaling
title_full Antiepithelial-Mesenchymal Transition of Herbal Active Substance in Tumor Cells via Different Signaling
title_fullStr Antiepithelial-Mesenchymal Transition of Herbal Active Substance in Tumor Cells via Different Signaling
title_full_unstemmed Antiepithelial-Mesenchymal Transition of Herbal Active Substance in Tumor Cells via Different Signaling
title_short Antiepithelial-Mesenchymal Transition of Herbal Active Substance in Tumor Cells via Different Signaling
title_sort antiepithelial-mesenchymal transition of herbal active substance in tumor cells via different signaling
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183534/
https://www.ncbi.nlm.nih.gov/pubmed/32377312
http://dx.doi.org/10.1155/2020/9253745
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AT linqinlu antiepithelialmesenchymaltransitionofherbalactivesubstanceintumorcellsviadifferentsignaling
AT huangping antiepithelialmesenchymaltransitionofherbalactivesubstanceintumorcellsviadifferentsignaling
AT liangying antiepithelialmesenchymaltransitionofherbalactivesubstanceintumorcellsviadifferentsignaling

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