Cargando…

Senolytic compounds control a distinct fate of androgen receptor agonist- and antagonist-induced cellular senescent LNCaP prostate cancer cells

BACKGROUND: The benefit of inducing cellular senescence as a tumor suppressive strategy remains questionable due to the senescence-associated secretory phenotype. Hence, studies and development of senolytic compounds that induce cell death in senescent cells have recently emerged. Senescent cells ar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pungsrinont, Thanakorn, Sutter, Malika Franziska, Ertingshausen, Maren C. C. M., Lakshmana, Gopinath, Kokal, Miriam, Khan, Amir Saeed, Baniahmad, Aria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183592/ https://www.ncbi.nlm.nih.gov/pubmed/32351687 http://dx.doi.org/10.1186/s13578-020-00422-2

Ejemplares similares

Mechanisms of Androgen Receptor Agonist- and Antagonist-Mediated Cellular Senescence in Prostate Cancer
por: Kokal, Miriam, et al.
Publicado: (2020)

Androgen receptor agonist and antagonist reduce response of cytokine‐induced killer cells on prostate cancer cells
por: Pungsrinont, Thanakorn, et al.
Publicado: (2023)

Interleukin-23 Represses the Level of Cell Senescence Induced by the Androgen Receptor Antagonists Enzalutamide and Darolutamide in Castration-Resistant Prostate Cancer Cells
por: Gupta, Siddharth, et al.
Publicado: (2020)

Role of PI3K-AKT-mTOR Pathway as a Pro-Survival Signaling and Resistance-Mediating Mechanism to Therapy of Prostate Cancer
por: Pungsrinont, Thanakorn, et al.
Publicado: (2021)

Alteration of Androgen Receptor Protein Stability by Triptolide in LNCaP Cells
por: Li, Wei, et al.
Publicado: (2018)

Androgen-independent LNCaP cells are a subline of LNCaP cells with a more aggressive phenotype and androgen suppresses their growth by inducing cell cycle arrest at the G1 phase
por: Yu, Pan, et al.
Publicado: (2017)

Androgen upregulates the palmitoylation of eIF3L in human prostate LNCaP cells
por: Cui, Luwei, et al.
Publicado: (2019)

ADAMTS1 alters blood vessel morphology and TSP1 levels in LNCaP and LNCaP-19 prostate tumors
por: Gustavsson, Heléne, et al.
Publicado: (2010)

Synthetic androgens suppress the transformed phenotype in the human prostate carcinoma cell line LNCaP.
por: Wolf, D. A., et al.
Publicado: (1991)

Effect of curcumin on the interaction between androgen receptor and Wnt/β-catenin in LNCaP xenografts
por: Hong, Jeong Hee, et al.
Publicado: (2015)

Chronic IL-1 exposure drives LNCaP cells to evolve androgen and AR independence
por: Dahl, Haley C., et al.
Publicado: (2020)

Role of Androgen Receptor in Progression of LNCaP Prostate Cancer Cells from G(1) to S Phase
por: Murthy, Shalini, et al.
Publicado: (2013)

Enhanced sensitivity to androgen withdrawal due to overexpression of interleukin-6 in androgen-dependent human prostate cancer LNCaP cells
por: Terakawa, T, et al.
Publicado: (2009)

CRISPR/Cas9 targeting of the androgen receptor suppresses the growth of LNCaP human prostate cancer cells
por: Wei, Chaogang, et al.
Publicado: (2018)

Ophiopogonin D' induces RIPK1-dependent necroptosis in androgen-dependent LNCaP prostate cancer cells
por: Lu, Zongliang, et al.
Publicado: (2019)

Efficacy of PACE4 pharmacotherapy in JHU-LNCaP-SM preclinical model of androgen independent prostate cancer
por: Mekdad, Nawel, et al.
Publicado: (2022)

Apogossypolone inhibits the proliferation of LNCaP cells in vitro and in vivo
por: ZHANG, XIANQING, et al.
Publicado: (2014)

Apogossypolone inhibits the proliferation of LNCaP cells in vitro and in vivo
por: Zhang, Xianqing, et al.
Publicado: (2018)

Fate of the human Y chromosome linked genes and loci in prostate cancer cell lines DU145 and LNCaP
por: Yadav, Sandeep Kumar, et al.
Publicado: (2013)

Senescence and Senolytics: State of the Art on Cellular Senescence, Senolytics, and Healthspan
por: Campisi, Judith
Publicado: (2020)

Optimal timing and dosage of chemotherapy as a combined treatment with androgen withdrawal in the human prostate LNCaP tumour model
por: Miyake, H, et al.
Publicado: (2001)

Heat shock protein 70 inhibitors suppress androgen receptor expression in LNCaP95 prostate cancer cells
por: Kita, Kazuaki, et al.
Publicado: (2017)

Cucurbitacin-B instigates intrinsic apoptosis and modulates Notch signaling in androgen-dependent prostate cancer LNCaP cells
por: Alafnan, Ahmed, et al.
Publicado: (2023)

Osteopontin-c mediates the upregulation of androgen responsive genes in LNCaP cells through PI3K/Akt and androgen receptor signaling
por: TILLI, TATIANA MARTINS, et al.
Publicado: (2015)

Calcitriol and TO-901317 Interact in Human Prostate Cancer LNCaP Cells
por: Wang, Jing-Huan, et al.
Publicado: (2008)

URG11 promotes proliferation and induced apoptosis of LNCaP cells
por: Sun, Chenmin, et al.
Publicado: (2019)

From the divergence of senescent cell fates to mechanisms and selectivity of senolytic drugs
por: L'Hôte, Valentin, et al.
Publicado: (2022)

HOXB13 promotes androgen independent growth of LNCaP prostate cancer cells by the activation of E2F signaling
por: Kim, Young-Rang, et al.
Publicado: (2010)

Down-regulation of DcR2 sensitizes androgen-dependent prostate cancer LNCaP cells to TRAIL-induced apoptosis
por: Vindrieux, David, et al.
Publicado: (2011)

Corrigendum: Cucurbitacin-B instigates intrinsic apoptosis and modulates Notch signaling in androgen-dependent prostate cancer LNCaP cells
por: Alafnan, Ahmed, et al.
Publicado: (2023)

Correlation Between PSMA and VEGF Expression as Markers for LNCaP Tumor Angiogenesis
por: Tsui, Paulus, et al.
Publicado: (2005)

Anti-Cancer Effect of Lambertianic Acid by Inhibiting the AR in LNCaP Cells
por: Lee, Myoung-Sun, et al.
Publicado: (2016)

Androgen Receptor Activity Is Affected by Both Nuclear Matrix Localization and the Phosphorylation Status of the Heterogeneous Nuclear Ribonucleoprotein K in Anti-Androgen-Treated LNCaP Cells
por: Barboro, Paola, et al.
Publicado: (2013)

Identification of Novel Androgen-Regulated Pathways and mRNA Isoforms through Genome-Wide Exon-Specific Profiling of the LNCaP Transcriptome
por: Rajan, Prabhakar, et al.
Publicado: (2011)

The F-box protein SKP2 mediates androgen control of p27 stability in LNCaP human prostate cancer cells
por: Lu, Lifang, et al.
Publicado: (2002)

Androgen deprivation in LNCaP prostate tumour xenografts induces vascular changes and hypoxic stress, resulting in promotion of epithelial-to-mesenchymal transition
por: Byrne, N M, et al.
Publicado: (2016)

Role of Testosterone Levels on the Combinatorial Effect of Boswellia serrata Extract and Enzalutamide on Androgen Dependent LNCaP Cells and in Patient Derived Cells
por: Pillai, Prathesha, et al.
Publicado: (2021)

Inhibition of Androgen Receptor Expression with Small Interfering RNA Enhances Cancer Cell Apoptosis by Suppressing Survival Factors in Androgen Insensitive, Late Stage LNCaP Cells
por: Kim, Sang Soo, et al.
Publicado: (2013)

Farnesoid X receptor inhibits LNcaP cell proliferation via the upregulation of PTEN
por: LIU, JUN, et al.
Publicado: (2014)

Valproic Acid Addresses Neuroendocrine Differentiation of LNCaP Cells and Maintains Cell Survival
por: Giordano, Francesca, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_eqrm065t3m5hcro6j4sg90he7a