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Do probiotics promote oral health during orthodontic treatment with fixed appliances? A systematic review
BACKGROUND: Treatment with fixed orthodontic appliances has been associated with significant biofilm accumulation, thus putting patients at a higher risk of oral health deterioration. The use of probiotics has been proposed to be useful in the prevention or treatment of oral pathologies such as cari...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183645/ https://www.ncbi.nlm.nih.gov/pubmed/32334590 http://dx.doi.org/10.1186/s12903-020-01109-3 |
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author | Hadj-Hamou, Riham Senok, Abiola C. Athanasiou, Athanasios E. Kaklamanos, Eleftherios G. |
author_facet | Hadj-Hamou, Riham Senok, Abiola C. Athanasiou, Athanasios E. Kaklamanos, Eleftherios G. |
author_sort | Hadj-Hamou, Riham |
collection | PubMed |
description | BACKGROUND: Treatment with fixed orthodontic appliances has been associated with significant biofilm accumulation, thus putting patients at a higher risk of oral health deterioration. The use of probiotics has been proposed to be useful in the prevention or treatment of oral pathologies such as caries and diseases of periodontal tissues. Our aim was to investigate the effects of probiotic use on inflammation of the gingival tissues and the decalcification of the enamel in patients being treated with fixed orthodontic appliances. METHODS: We searched without restrictions 8 databases and performed hand searching until September 2019. We searched for randomized controlled trials (RCTs) evaluating whether individuals with fixed orthodontic appliances benefit from probiotic treatment in terms of the inflammation of the gingivae and decalcification of the enamel. Following the selection of studies and the extraction of pertinent data, we appraised the risk of bias and the confidence in the observed effects based on established methodologies. RESULTS: From the final qualifying studies, three did not show any statistically significant effect on gingival inflammation after probiotic administration of up to 1 month. Similarly, non-significant differences were noted in another study regarding white spot lesions development (mean administration for 17 months). No adverse effects were reported and the level of evidence was considered moderate. CONCLUSIONS: Supplementation of orthodontic patients with probiotics did not affect the development of inflammation in the gingivae and decalcification in the enamel. Additional RCTs, with longer intervention and follow-up periods, and involving different combinations of probiotic strains are required. TRIAL REGISTRATION: PROSPERO (CRD42018118008) |
format | Online Article Text |
id | pubmed-7183645 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-71836452020-04-29 Do probiotics promote oral health during orthodontic treatment with fixed appliances? A systematic review Hadj-Hamou, Riham Senok, Abiola C. Athanasiou, Athanasios E. Kaklamanos, Eleftherios G. BMC Oral Health Research Article BACKGROUND: Treatment with fixed orthodontic appliances has been associated with significant biofilm accumulation, thus putting patients at a higher risk of oral health deterioration. The use of probiotics has been proposed to be useful in the prevention or treatment of oral pathologies such as caries and diseases of periodontal tissues. Our aim was to investigate the effects of probiotic use on inflammation of the gingival tissues and the decalcification of the enamel in patients being treated with fixed orthodontic appliances. METHODS: We searched without restrictions 8 databases and performed hand searching until September 2019. We searched for randomized controlled trials (RCTs) evaluating whether individuals with fixed orthodontic appliances benefit from probiotic treatment in terms of the inflammation of the gingivae and decalcification of the enamel. Following the selection of studies and the extraction of pertinent data, we appraised the risk of bias and the confidence in the observed effects based on established methodologies. RESULTS: From the final qualifying studies, three did not show any statistically significant effect on gingival inflammation after probiotic administration of up to 1 month. Similarly, non-significant differences were noted in another study regarding white spot lesions development (mean administration for 17 months). No adverse effects were reported and the level of evidence was considered moderate. CONCLUSIONS: Supplementation of orthodontic patients with probiotics did not affect the development of inflammation in the gingivae and decalcification in the enamel. Additional RCTs, with longer intervention and follow-up periods, and involving different combinations of probiotic strains are required. TRIAL REGISTRATION: PROSPERO (CRD42018118008) BioMed Central 2020-04-25 /pmc/articles/PMC7183645/ /pubmed/32334590 http://dx.doi.org/10.1186/s12903-020-01109-3 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Hadj-Hamou, Riham Senok, Abiola C. Athanasiou, Athanasios E. Kaklamanos, Eleftherios G. Do probiotics promote oral health during orthodontic treatment with fixed appliances? A systematic review |
title | Do probiotics promote oral health during orthodontic treatment with fixed appliances? A systematic review |
title_full | Do probiotics promote oral health during orthodontic treatment with fixed appliances? A systematic review |
title_fullStr | Do probiotics promote oral health during orthodontic treatment with fixed appliances? A systematic review |
title_full_unstemmed | Do probiotics promote oral health during orthodontic treatment with fixed appliances? A systematic review |
title_short | Do probiotics promote oral health during orthodontic treatment with fixed appliances? A systematic review |
title_sort | do probiotics promote oral health during orthodontic treatment with fixed appliances? a systematic review |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183645/ https://www.ncbi.nlm.nih.gov/pubmed/32334590 http://dx.doi.org/10.1186/s12903-020-01109-3 |
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