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Prevalence of familial cluster headache: a systematic review and meta-analysis

INTRODUCTION: The population rate of familial cluster headache (CH) has been reported to be as high as 20% however this varies considerably across studies. To obtain a true estimate of family history in CH, we conducted a systematic review and meta-analysis of previously published data. METHODS: Our...

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Autores principales: O’Connor, Emer, Simpson, Benjamin S., Houlden, Henry, Vandrovcova, Jana, Matharu, Manjit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183702/
https://www.ncbi.nlm.nih.gov/pubmed/32334514
http://dx.doi.org/10.1186/s10194-020-01101-w
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author O’Connor, Emer
Simpson, Benjamin S.
Houlden, Henry
Vandrovcova, Jana
Matharu, Manjit
author_facet O’Connor, Emer
Simpson, Benjamin S.
Houlden, Henry
Vandrovcova, Jana
Matharu, Manjit
author_sort O’Connor, Emer
collection PubMed
description INTRODUCTION: The population rate of familial cluster headache (CH) has been reported to be as high as 20% however this varies considerably across studies. To obtain a true estimate of family history in CH, we conducted a systematic review and meta-analysis of previously published data. METHODS: Our systematic review involved a search of electronic databases (Medline, EMBASE, PubMed, CINAHL) to identify and appraise studies of interest utilising the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) guidelines. To further ameliorate the accuracy of our analysis we included an additional unpublished cohort of CH patients recruited at a tertiary referral centre for headache, who underwent detailed family history with diagnostic verification in relatives. Data was extracted and meta-analysis conducted to provide a true estimation of family history. RESULTS: In total, we identified 7 studies which fulfilled our inclusion criteria. The estimated true prevalence of CH patients with a positive family history was 6.27% (95% CI:4.65–8.40%) with an overall I(2) of 73%. Fitted models for gender subgroups showed higher estimates 9.26% (95% CI: 6.29–13.43%) in females. However the I(2) for the female model was 58.42% and significant (p = 0.047). CONCLUSION: Our findings estimate a rate of family history in CH to be approximately 6.27% (95% CI: 4.65–8.40%). While estimates were larger for female probands, we demonstrated high heterogeneity in this subgroup. These findings further support a genetic role in the aetiology of CH.
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spelling pubmed-71837022020-04-29 Prevalence of familial cluster headache: a systematic review and meta-analysis O’Connor, Emer Simpson, Benjamin S. Houlden, Henry Vandrovcova, Jana Matharu, Manjit J Headache Pain Research Article INTRODUCTION: The population rate of familial cluster headache (CH) has been reported to be as high as 20% however this varies considerably across studies. To obtain a true estimate of family history in CH, we conducted a systematic review and meta-analysis of previously published data. METHODS: Our systematic review involved a search of electronic databases (Medline, EMBASE, PubMed, CINAHL) to identify and appraise studies of interest utilising the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) guidelines. To further ameliorate the accuracy of our analysis we included an additional unpublished cohort of CH patients recruited at a tertiary referral centre for headache, who underwent detailed family history with diagnostic verification in relatives. Data was extracted and meta-analysis conducted to provide a true estimation of family history. RESULTS: In total, we identified 7 studies which fulfilled our inclusion criteria. The estimated true prevalence of CH patients with a positive family history was 6.27% (95% CI:4.65–8.40%) with an overall I(2) of 73%. Fitted models for gender subgroups showed higher estimates 9.26% (95% CI: 6.29–13.43%) in females. However the I(2) for the female model was 58.42% and significant (p = 0.047). CONCLUSION: Our findings estimate a rate of family history in CH to be approximately 6.27% (95% CI: 4.65–8.40%). While estimates were larger for female probands, we demonstrated high heterogeneity in this subgroup. These findings further support a genetic role in the aetiology of CH. Springer Milan 2020-04-25 /pmc/articles/PMC7183702/ /pubmed/32334514 http://dx.doi.org/10.1186/s10194-020-01101-w Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
O’Connor, Emer
Simpson, Benjamin S.
Houlden, Henry
Vandrovcova, Jana
Matharu, Manjit
Prevalence of familial cluster headache: a systematic review and meta-analysis
title Prevalence of familial cluster headache: a systematic review and meta-analysis
title_full Prevalence of familial cluster headache: a systematic review and meta-analysis
title_fullStr Prevalence of familial cluster headache: a systematic review and meta-analysis
title_full_unstemmed Prevalence of familial cluster headache: a systematic review and meta-analysis
title_short Prevalence of familial cluster headache: a systematic review and meta-analysis
title_sort prevalence of familial cluster headache: a systematic review and meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183702/
https://www.ncbi.nlm.nih.gov/pubmed/32334514
http://dx.doi.org/10.1186/s10194-020-01101-w
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