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AID in Antibody Diversification: There and Back Again

Activation-Induced cytidine Deaminase (AID) initiates affinity maturation and isotype switching by deaminating deoxycytidines within immunoglobulin genes, leading to somatic hypermutation (SHM) and class switch recombination (CSR). AID thus potentiates the humoral response to clear pathogens. Markin...

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Detalles Bibliográficos
Autores principales:	Feng, Yuqing, Seija, Noé, Di Noia, Javier M., Martin, Alberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Ltd. 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183997/ https://www.ncbi.nlm.nih.gov/pubmed/32434680 http://dx.doi.org/10.1016/j.it.2020.04.009

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