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Association of Common Carotid Artery Measurements with N-terminal Pro B-type Natriuretic Peptide in Elderly Participants

OBJECTIVE: Numerous studies have reported an association between common carotid artery (CCA) parameters and atherosclerotic cardiovascular disease (CVD). However, the association between CCA parameters and hemodynamic stress on the left ventricle in elderly patients remains unclear. METHODS: We asse...

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Autores principales: Sasaki, Nobuo, Yamamoto, Hideya, Ozono, Ryoji, Maeda, Ryo, Kihara, Yasuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184082/
https://www.ncbi.nlm.nih.gov/pubmed/31787700
http://dx.doi.org/10.2169/internalmedicine.3780-19
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author Sasaki, Nobuo
Yamamoto, Hideya
Ozono, Ryoji
Maeda, Ryo
Kihara, Yasuki
author_facet Sasaki, Nobuo
Yamamoto, Hideya
Ozono, Ryoji
Maeda, Ryo
Kihara, Yasuki
author_sort Sasaki, Nobuo
collection PubMed
description OBJECTIVE: Numerous studies have reported an association between common carotid artery (CCA) parameters and atherosclerotic cardiovascular disease (CVD). However, the association between CCA parameters and hemodynamic stress on the left ventricle in elderly patients remains unclear. METHODS: We assessed CCA parameters, including the height-adjusted CCA interadventitial diameter (diameter/height), mean intima-media thickness (IMT), number of plaques, plaque score, resistance index (RI), and pulsatility index (PI) with ultrasonography, using serum N-terminal pro-brain natriuretic peptide (NT-proBNP) levels as a marker for hemodynamic stress on the left ventricle in 1,315 participants ≥70 years old without CVD. Of these participants, 706 had hypertension, defined as taking antihypertensive medications, having a systolic blood pressure ≥140 mmHg, and/or having a diastolic blood pressure ≥90 mmHg. RESULTS: After adjusting for the confounding factors, the CCA interadventitial diameter/height was significantly associated with the log NT-proBNP in both the normotensive group (β=0.125, p=0.002) and hypertensive group (β=0.080, p=0.029). The RI was significantly associated with the log NT-proBNP in the hypertensive group (β=0.176, p<0.001) but not in the normotensive group. In addition, the PI was significantly associated with the log NT-proBNP in the hypertensive group (β=0.156, p<0.001) but not in the normotensive group. However, no significant association was observed between the mean IMT, number of plaques, and plaque score and log NT-proBNP. CONCLUSION: CCA measurements may be useful markers for hemodynamic stress on the left ventricle in elderly patients.
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spelling pubmed-71840822020-04-29 Association of Common Carotid Artery Measurements with N-terminal Pro B-type Natriuretic Peptide in Elderly Participants Sasaki, Nobuo Yamamoto, Hideya Ozono, Ryoji Maeda, Ryo Kihara, Yasuki Intern Med Original Article OBJECTIVE: Numerous studies have reported an association between common carotid artery (CCA) parameters and atherosclerotic cardiovascular disease (CVD). However, the association between CCA parameters and hemodynamic stress on the left ventricle in elderly patients remains unclear. METHODS: We assessed CCA parameters, including the height-adjusted CCA interadventitial diameter (diameter/height), mean intima-media thickness (IMT), number of plaques, plaque score, resistance index (RI), and pulsatility index (PI) with ultrasonography, using serum N-terminal pro-brain natriuretic peptide (NT-proBNP) levels as a marker for hemodynamic stress on the left ventricle in 1,315 participants ≥70 years old without CVD. Of these participants, 706 had hypertension, defined as taking antihypertensive medications, having a systolic blood pressure ≥140 mmHg, and/or having a diastolic blood pressure ≥90 mmHg. RESULTS: After adjusting for the confounding factors, the CCA interadventitial diameter/height was significantly associated with the log NT-proBNP in both the normotensive group (β=0.125, p=0.002) and hypertensive group (β=0.080, p=0.029). The RI was significantly associated with the log NT-proBNP in the hypertensive group (β=0.176, p<0.001) but not in the normotensive group. In addition, the PI was significantly associated with the log NT-proBNP in the hypertensive group (β=0.156, p<0.001) but not in the normotensive group. However, no significant association was observed between the mean IMT, number of plaques, and plaque score and log NT-proBNP. CONCLUSION: CCA measurements may be useful markers for hemodynamic stress on the left ventricle in elderly patients. The Japanese Society of Internal Medicine 2019-11-29 2020-04-01 /pmc/articles/PMC7184082/ /pubmed/31787700 http://dx.doi.org/10.2169/internalmedicine.3780-19 Text en Copyright © 2020 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Sasaki, Nobuo
Yamamoto, Hideya
Ozono, Ryoji
Maeda, Ryo
Kihara, Yasuki
Association of Common Carotid Artery Measurements with N-terminal Pro B-type Natriuretic Peptide in Elderly Participants
title Association of Common Carotid Artery Measurements with N-terminal Pro B-type Natriuretic Peptide in Elderly Participants
title_full Association of Common Carotid Artery Measurements with N-terminal Pro B-type Natriuretic Peptide in Elderly Participants
title_fullStr Association of Common Carotid Artery Measurements with N-terminal Pro B-type Natriuretic Peptide in Elderly Participants
title_full_unstemmed Association of Common Carotid Artery Measurements with N-terminal Pro B-type Natriuretic Peptide in Elderly Participants
title_short Association of Common Carotid Artery Measurements with N-terminal Pro B-type Natriuretic Peptide in Elderly Participants
title_sort association of common carotid artery measurements with n-terminal pro b-type natriuretic peptide in elderly participants
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184082/
https://www.ncbi.nlm.nih.gov/pubmed/31787700
http://dx.doi.org/10.2169/internalmedicine.3780-19
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