Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice

Cellular senescence, a persistent state of cell cycle arrest, accumulates in aged organisms, contributes to tissue dysfunction, and drives age-related phenotypes. The clearance of senescent cells is expected to decrease chronic, low-grade inflammation and improve tissue repair capacity, thus attenua...

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Detalles Bibliográficos
Autores principales: Cai, Yusheng, Zhou, Huanhuan, Zhu, Yinhua, Sun, Qi, Ji, Yin, Xue, Anqi, Wang, Yuting, Chen, Wenhan, Yu, Xiaojie, Wang, Longteng, Chen, Han, Li, Cheng, Luo, Tuoping, Deng, Hongkui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184167/
https://www.ncbi.nlm.nih.gov/pubmed/32341413
http://dx.doi.org/10.1038/s41422-020-0314-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184167/
https://www.ncbi.nlm.nih.gov/pubmed/32341413
http://dx.doi.org/10.1038/s41422-020-0314-9

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